(a)
(b)
(c)
Figure 3: Cold allodynia and mechanical and thermal hyperalgesia. The number of responses to cold (n = 6), mechanical (n = 7), and thermal (n = 8) stimuli at the hind paw of the cancer animals is measured. (a) Substantial increase of cold allodynia from day 6 to day 14 () as indicated by an increased number of responses. (b) Significant increase of mechanical hyperalgesia from day 6 to day 14 () as indicated by decreased applied forces. (c) Thermal hyperalgesia significantly decreases at day 2 () followed by an increase from day 6 to day 14 (). Time points are all compared with control (day zero).