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Pain Research and Management
Volume 2017, Article ID 3517207, 12 pages
https://doi.org/10.1155/2017/3517207
Research Article

A Novel Model of Cancer-Induced Peripheral Neuropathy and the Role of TRPA1 in Pain Transduction

1Department of Anesthesiology and Operative Intensive Care Medicine, Campuses Mitte and Virchow-Klinikum, Charité–University of Medicine Berlin, Berlin, Germany
2Department of Biochemistry, College of Pharmacy, Al-Azhar University, Asyût, Egypt

Correspondence should be addressed to Ahmad Maqboul; ed.etirahc@luobqam.damha

Received 15 July 2017; Revised 16 October 2017; Accepted 2 November 2017; Published 28 December 2017

Academic Editor: Xing-Jun Liu

Copyright © 2017 Ahmad Maqboul and Bakheet Elsadek. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Liebig, G. Ayala, J. A. Wilks, D. H. Berger, and D. Albo, “Perineural invasion in cancer: a review of the literature,” Cancer, vol. 115, no. 15, pp. 3379–3391, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. P. W. Mantyh, D. R. Clohisy, M. Koltzenburg, and S. P. Hunt, “Molecular mechanisms of cancer pain,” Nature Reviews Cancer, vol. 2, no. 3, pp. 201–209, 2002. View at Publisher · View at Google Scholar
  3. H. Dai, R. Li, T. Wheeler et al., “Enhanced survival in perineural invasion of pancreatic cancer: an in vitro approach,” Human Pathology, vol. 38, no. 2, pp. 299–307, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. P. D. Wall, J. W. Scadding, and M. M. Tomkiewicz, “The production and prevention of experimental anesthesia dolorosa,” Pain, vol. 6, no. 2, pp. 175–182, 1979. View at Publisher · View at Google Scholar · View at Scopus
  5. G. J. Bennett and Y. K. Xie, “A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man,” Pain, vol. 33, no. 1, pp. 87–107, 1988. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Shimoyama, K. Tanaka, F. Hasue, and N. Shimoyama, “A mouse model of neuropathic cancer pain,” Pain, vol. 99, no. 1, pp. 167–174, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Hald, S. Nedergaard, R. R. Hansen, M. Ding, and A. M. Heegaard, “Differential activation of spinal cord glial cells in murine models of neuropathic and cancer pain,” European Journal of Pain, vol. 13, no. 2, pp. 138–145, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Wei, Y. Wei, F. Tian, T. Niu, and G. Yi, “Blocking proteinase-activated receptor 2 alleviated neuropathic pain evoked by spinal cord injury,” Physiological Research/Academia Scientiarum Bohemoslovaca, vol. 65, no. 1, pp. 145–153, 2016. View at Google Scholar
  9. I. B. Philyppov, O. N. Paduraru, K. L. Gulak, R. Skryma, N. Prevarskaya, and Y. M. Shuba, “TRPA1-dependent regulation of bladder detrusor smooth muscle contractility in normal and type I diabetic rats,” Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai kikanshi, vol. 52, pp. 1–17, 2016. View at Publisher · View at Google Scholar · View at Scopus
  10. J. J. DeBerry, E. S. Schwartz, and B. M. Davis, “TRPA1 mediates bladder hyperalgesia in a mouse model of cystitis,” Pain, vol. 155, no. 7, pp. 1280–1287, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. M. C. Dall'Acqua, I. J. Bonet, A. R. Zampronio, C. H. Tambeli, C. A. Parada, and L. Fischer, “The contribution of transient receptor potential ankyrin 1 (TRPA1) to the in vivo nociceptive effects of prostaglandin E2,” Life Sciences, vol. 105, no. 1-2, pp. 7–13, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. I. J. Bonet, L. Fischer, C. A. Parada, and C. H. Tambeli, “The role of transient receptor potential A 1 (TRPA1) in the development and maintenance of carrageenan-induced hyperalgesia,” Neuropharmacology, vol. 65, pp. 206–212, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Mergler, Y. Cheng, S. Skosyrski et al., “Altered calcium regulation by thermosensitive transient receptor potential channels in etoposide-resistant WERI-Rb1 retinoblastoma cells,” Experimental Eye Research, vol. 94, no. 1, pp. 157–173, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. I. Mukhopadhyay, P. Gomes, S. Aranake et al., “Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells,” Journal of Receptors and Signal Transduction, vol. 31, no. 5, pp. 350–358, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. I. Kaji, Y. Yasuoka, S. Karaki, and A. Kuwahara, “Activation of TRPA1 by luminal stimuli induces EP4-mediated anion secretion in human and rat colon,” American Journal of Physiology Gastrointestinal and Liver Physiology, vol. 302, no. 7, pp. G690–G701, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Uckert, J. E. Sonnenberg, K. Albrecht, M. A. Kuczyk, and P. Hedlund, “Expression and distribution of the transient receptor potential cationic channel ankyrin 1 (TRPA1) in the human vagina,” International Journal of Impotence Research, vol. 27, no. 1, pp. 16–19, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. M. H. Oh, S. Y. Oh, J. Lu et al., “TRPA1-dependent pruritus in IL-13-induced chronic atopic dermatitis,” Journal of Immunology, vol. 191, no. 11, pp. 5371–5382, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. K. J. Zappia, S. R. Garrison, O. Palygin et al., “Mechanosensory and ATP release deficits following keratin14-Cre-mediated TRPA1 deletion despite absence of TRPA1 in murine keratinocytes,” PLoS One, vol. 11, no. 3, p. e0151602, 2016. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Ruparel, M. Bendele, A. Wallace, and D. Green, “Released lipids regulate transient receptor potential channel (TRP)-dependent oral cancer pain,” Molecular Pain, vol. 11, p. 30, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Ye, D. Dang, J. Zhang et al., “Nerve growth factor links oral cancer progression, pain, and cachexia,” Molecular Cancer Therapeutics, vol. 10, no. 9, pp. 1667–1676, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. S. D. Brain, T. J. Williams, J. R. Tippins, H. R. Morris, and I. MacIntyre, “Calcitonin gene-related peptide is a potent vasodilator,” Nature, vol. 313, no. 5997, pp. 54–56, 1985. View at Publisher · View at Google Scholar · View at Scopus
  22. D. L. Hay, C. S. Walker, and D. R. Poyner, “Adrenomedullin and calcitonin gene-related peptide receptors in endocrine-related cancers: opportunities and challenges,” Endocrine Related Cancer, vol. 18, no. 1, pp. C1–C14, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. R. R. Hansen, V. Vacca, T. Pitcher, A. K. Clark, and M. Malcangio, “Role of extracellular calcitonin gene-related peptide in spinal cord mechanisms of cancer-induced bone pain,” Pain, vol. 157, no. 3, pp. 666–676, 2016. View at Publisher · View at Google Scholar · View at Scopus
  24. W. S. Schou, S. Ashina, F. M. Amin, P. J. Goadsby, and M. Ashina, “Calcitonin gene-related peptide and pain: a systematic review,” The Journal of Headache and Pain, vol. 18, no. 1, p. 34, 2017. View at Publisher · View at Google Scholar
  25. S. M. Mueller-Tribbensee, M. Karna, M. Khalil, M. F. Neurath, P. W. Reeh, and M. A. Engel, “Differential contribution of TRPA1, TRPV4 and TRPM8 to colonic nociception in mice,” PLoS One, vol. 10, no. 7, p. e0128242, 2015. View at Publisher · View at Google Scholar · View at Scopus
  26. B. X. Huang, W. L. Cao, X. Huang et al., “Expressions of transient receptor potential A1 and related inflammatory factors in the rat model of prostatic inflammation,” Zhonghua Nan Ke Xue = National Journal of Andrology, vol. 21, no. 1, pp. 23–30, 2015. View at Google Scholar
  27. V. Meseguer, Y. A. Alpizar, E. Luis et al., “TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins,” Nature Communications, vol. 5, p. 3125, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Festing and J. Staats, “Standardized nomenclature for inbred strains of rats: fourth listing,” Transplantation, vol. 16, no. 3, pp. 221–245, 1973. View at Publisher · View at Google Scholar
  29. J. T. Isaacs, W. B. Isaacs, W. F. Feitz, and J. Scheres, “Establishment and characterization of seven Dunning rat prostatic cancer cell lines and their use in developing methods for predicting metastatic abilities of prostatic cancers,” Prostate, vol. 9, no. 3, pp. 261–281, 1986. View at Publisher · View at Google Scholar · View at Scopus
  30. F. D. Bullock and M. R. Curtis, “Spontaneous tumors of the rat,” Journal of Cancer Research, vol. 14, no. 1, pp. 1–115, 1930. View at Publisher · View at Google Scholar · View at Scopus
  31. W. F. Dunning and M. R. Curtis, “The respective roles of longevity and genetic specificity in the occurrence of spontaneous tumors in the hybrids between two inbred lines of rats,” Cancer Research, vol. 6, pp. 61–81, 1946. View at Google Scholar
  32. W. F. Dunning, “Prostate cancer in the rat,” National Cancer Institute Monograph, vol. 12, pp. 351–369, 1963. View at Google Scholar
  33. M. F. W. Festing, “Chapter 3 - Inbred strains,” in The Laboratory Rat, H. J. Baker, J. R. Lindsey, and S. H. Weisbroth, Eds., pp. 55–72, Academic Press, 1979. View at Publisher · View at Google Scholar
  34. H. Xing, M. Chen, J. Ling, W. Tan, and J. G. Gu, “TRPM8 mechanism of cold allodynia after chronic nerve injury,” Journal of Neuroscience, vol. 27, no. 50, pp. 13680–13690, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. L. Bardin, N. Malfetes, A. Newman-Tancredi, and R. Depoortere, “Chronic restraint stress induces mechanical and cold allodynia, and enhances inflammatory pain in rat: relevance to human stress-associated painful pathologies,” Behavioural Brain Research, vol. 205, no. 2, pp. 360–366, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. W. T. Dixon, “The up-and-down method for small samples,” Journal of the American Statistical Association, vol. 60, no. 312, pp. 967–978, 1965. View at Publisher · View at Google Scholar · View at Scopus
  37. S. R. Chaplan, F. W. Bach, J. W. Pogrel, J. M. Chung, and T. L. Yaksh, “Quantitative assessment of tactile allodynia in the rat paw,” Journal of Neuroscience Methods, vol. 53, no. 1, pp. 55–63, 1994. View at Publisher · View at Google Scholar · View at Scopus
  38. W. J. Dixon, “Efficient analysis of experimental observations,” Annual Review of Pharmacology and Toxicology, vol. 20, no. 1, pp. 441–462, 1980. View at Publisher · View at Google Scholar
  39. K. Hargreaves, R. Dubner, F. Brown, C. Flores, and J. Joris, “A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia,” Pain, vol. 32, no. 1, pp. 77–88, 1988. View at Publisher · View at Google Scholar · View at Scopus
  40. H. Towbin, T. Staehelin, and J. Gordon, “Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. 1979,” Biotechnology, vol. 24, pp. 145–149, 1992. View at Google Scholar
  41. J. Schindelin, I. Arganda-Carreras, E. Frise et al., “Fiji: an open-source platform for biological-image analysis,” Nature Methods, vol. 9, no. 7, pp. 676–682, 2012. View at Publisher · View at Google Scholar · View at Scopus
  42. B. Chazotte, “Labeling nuclear DNA using DAPI,” Cold Spring Harbor Protocols, vol. 2011, no. 1, p. pdb prot5556, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. T. D. Schmittgen and B. A. Zakrajsek, “Effect of experimental treatment on housekeeping gene expression: validation by real-time, quantitative RT-PCR,” Journal of Biochemical and Biophysical Methods, vol. 46, no. 1-2, pp. 69–81, 2000. View at Publisher · View at Google Scholar · View at Scopus
  44. P. Honore, S. D. Rogers, M. J. Schwei et al., “Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons,” Neuroscience, vol. 98, no. 3, pp. 585–598, 2000. View at Publisher · View at Google Scholar · View at Scopus
  45. A. P. Bloom, J. M. Jimenez-Andrade, R. N. Taylor et al., “Breast cancer-induced bone remodeling, skeletal pain, and sprouting of sensory nerve fibers,” Journal of Pain, vol. 12, no. 6, pp. 698–711, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. S. P. Alexander, K. Mackie, and R. A. Ross, “Themed issue: cannabinoids,” British Journal of Pharmacology, vol. 160, no. 3, pp. 421-422, 2010. View at Publisher · View at Google Scholar · View at Scopus
  47. T. Donovan-Rodriguez, A. H. Dickenson, and C. E. Urch, “Superficial dorsal horn neuronal responses and the emergence of behavioural hyperalgesia in a rat model of cancer-induced bone pain,” Neuroscience Letters, vol. 360, no. 1-2, pp. 29–32, 2004. View at Publisher · View at Google Scholar · View at Scopus
  48. P. Peng, Q. Xi, S. Xia et al., “Pregabalin attenuates docetaxel-induced neuropathy in rats,” Journal of Huazhong University of Science and Technology Medical Sciences, vol. 32, no. 4, pp. 586–590, 2012. View at Publisher · View at Google Scholar · View at Scopus
  49. G. Calcott, J. P. White, and I. Nagy, “Xenon fails to inhibit capsaicin-evoked CGRP release by nociceptors in culture,” Neuroscience Letters, vol. 499, no. 2, pp. 124–126, 2011. View at Publisher · View at Google Scholar · View at Scopus
  50. N. G. Gracias, T. R. Cummins, M. R. Kelley, D. P. Basile, T. Iqbal, and M. R. Vasko, “Vasodilatation in the rat dorsal hindpaw induced by activation of sensory neurons is reduced by paclitaxel,” Neurotoxicology, vol. 32, no. 1, pp. 140–149, 2011. View at Publisher · View at Google Scholar · View at Scopus
  51. M. E. Barabas, E. A. Kossyreva, and C. L. Stucky, “TRPA1 is functionally expressed primarily by IB4-binding, non-peptidergic mouse and rat sensory neurons,” PLoS One, vol. 7, no. 10, p. e47988, 2012. View at Publisher · View at Google Scholar · View at Scopus
  52. T. Kondo, T. Oshima, K. Obata et al., “Role of transient receptor potential A1 in gastric nociception,” Digestion, vol. 82, no. 3, pp. 150–155, 2010. View at Publisher · View at Google Scholar · View at Scopus
  53. F. Cattaruzza, I. Spreadbury, M. Miranda-Morales, E. F. Grady, S. Vanner, and N. W. Bunnett, “Transient receptor potential ankyrin-1 has a major role in mediating visceral pain in mice,” American Journal of Physiology Gastrointestinal and Liver Physiology, vol. 298, no. 1, pp. G81–G91, 2010. View at Publisher · View at Google Scholar · View at Scopus
  54. T. Kondo, K. Obata, K. Miyoshi et al., “Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats,” Gut, vol. 58, no. 10, pp. 1342–1352, 2009. View at Publisher · View at Google Scholar · View at Scopus
  55. D. J. Miller, P. Balaram, N. A. Young, and J. H. Kaas, “Three counting methods agree on cell and neuron number in chimpanzee primary visual cortex,” Frontiers in Neuroanatomy, vol. 8, p. 36, 2014. View at Publisher · View at Google Scholar · View at Scopus
  56. R. J. Mullen, C. R. Buck, and A. M. Smith, “NeuN, a neuronal specific nuclear protein in vertebrates,” Development, vol. 116, no. 1, pp. 201–211, 1992. View at Google Scholar