The Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines

Figure 4

Changes in mRNA levels of interleukin-6 (IL-6), IL-1β, and tumor necrosis factor α (TNF-α) after LED irradiation. Compared with the C groups, significant upregulation of IL-1β, IL-6, and TNF-α was noted in all the I groups (a, b, and c). Significantly decreased expression of IL-6 was noted in all the LED-irradiated groups compared with the incision only group (a). After LED irradiation, significantly decreased expression of IL-1β and TNF-α was noted only in the L-I group (b, c). C indicates LED irradiation for 6 days on sham skin incision in the paw contralateral to the LED-irradiated paw; I indicates incision only; L-I indicates LED irradiation for 6 days before skin incision; I-L indicates LED irradiation for 6 days after skin incision; L-I-L indicates LED irradiation from 3 days before skin incision to 3 days after skin incision. compared with the C and LED-irradiated groups; compared with the C groups. The values represent the means ± SD.

(a)

(b)

(c)