A Preliminary Genome-Wide Association Study of Pain-Related Fear: Implications for Orofacial Pain

Figure 1

Manhattan plots (a) show the –log₁₀-transformed value (-axis), indicating significance of the association, for each SNP across the genome (-axis; organized by physical position on each chromosome). The horizontal dashed lined indicates the threshold for genome-wide significance. Quantile-quantile plots (b) show the –log₁₀-transformed values observed in the GWAS (-axis) plotted against the expected distribution of values under the null hypothesis of no association. Chromosome 23 is the X chromosome.

(a)

(b)