A Preliminary Genome-Wide Association Study of Pain-Related Fear: Implications for Orofacial Pain

Table 7

Results for the leading SNP for loci showing significant or suggestive evidence of association with fear of pain.

Phenotype	SNP	Chr.	BP	A1	A2	MAF	Type	Info	Beta
Total	rs73782827	6	161667052	G	T	0.01	Imputed	0.91	−10.84
	rs112510117	8	125429261	A	G	0.01	Imputed	0.912	−8.44
	rs7084783	10	105324170	G	A	0.49	Imputed	0.982	−1.69
	rs56875752	17	12599002	C	A	0.11	Imputed	0.976	2.91
Minor	rs1146361	1	116658817	C	T	0.15	Imputed	0.994	−0.81
	rs6542838	2	99452458	C	T	0.44	Imputed	0.997	−0.61
	rs113865232	2	225213815	T	C	0.01	Imputed	0.986	−2.63
	rs13411339	2	237231135	T	C	0.03	Imputed	0.961	−1.77
	rs9871066	3	97202242	G	A	0.02	Imputed	0.993	−2.56
	rs2699039	4	160353222	A	G	0.02	Imputed	0.993	−2.54
	rs73746987	6	71820675	T	C	0.01	Imputed	0.974	−3.40
	rs73782827	6	161667052	G	T	0.01	Imputed	0.91	−3.80
	rs34139189	6	162293644	G	A	0.14	Imputed	0.796	−0.93
	rs73547001	8	24862630	G	A	0.01	Imputed	0.89	−3.35
	rs73700552	8	107068214	C	T	0.01	Imputed	0.969	−3.43
	rs113248907	8	125418123	A	C	0.01	Imputed	0.95	−3.41
	rs1871535	8	145639586	C	T	0.02	Imputed	0.878	−2.09
	rs12252682	10	93810742	C	G	0.02	Imputed	0.852	−2.45
	rs687735	11	64047152	A	G	0.01	Imputed	0.874	−3.26
	rs11871659	17	40692638	C	T	0.03	Imputed	0.979	−2.08
	rs2223785	20	30676316	C	T	0.02	Imputed	0.968	−2.80
	rs6008192	22	47804243	T	G	0.01	Imputed	0.931	−2.99
	rs73558352	23	123751759	T	G	0.02	Imputed	0.639	−2.00
Severe	rs553086	11	56852098	A	G	0.23	Genotyped	1	0.92
	rs10844026	12	31994740	A	T	0.24	Imputed	0.995	−0.95
	rs61923480	12	54884202	C	A	0.02	Imputed	0.915	2.52
	rs61930374	12	71271433	C	G	0.20	Imputed	0.933	−1.09
	rs112664965	13	51050827	A	G	0.04	Imputed	0.997	−1.88
	rs7178691	15	53899306	A	G	0.32	Imputed	1	−0.82
	rs56875752	17	12599002	C	A	0.11	Imputed	0.976	1.38
	rs3975333	19	53805815	T	A	0.09	Imputed	0.793	1.49
Medical	rs114134414	1	74708559	C	A	0.03	Imputed	0.899	2.15
	chr2:99411513	2	99411513	A	T	0.14	Imputed	0.719	−1.29
	rs72965720	6	128023381	C	A	0.08	Imputed	0.999	1.43
	rs9901616	17	29336745	T	C	0.03	Imputed	0.895	−2.31
	rs10422046	19	982968	A	G	0.11	Imputed	0.761	1.38
	rs5979239	23	10009993	A	G	0.04	Imputed	0.972	−2.04

Note. chr. = chromosome; BP = base position; A1 = minor (effect) allele; A2 = major allele; MAF = minor allele frequency; info = imputation information metric, an indicator imputation quality; beta = effect size per minor allele.