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Pain Research and Management
Volume 2017, Article ID 8560652, 18 pages
Review Article

Effectiveness of Low-Level Laser Therapy in Reducing Orthodontic Pain: A Systematic Review and Meta-Analysis

1Master Program in Dentistry, Faculty of Dentistry, Universidad de La Frontera, Temuco, Chile
2Department of Pediatric Dentistry and Orthodontics, Faculty of Dentistry, Universidad de La Frontera, Temuco, Chile
3Faculty of Dentistry, Universidad San Sebastian, Puerto Montt, Chile
4Applied Morphology Research Centre (CIMA), Faculty of Dentistry, Universidad de La Frontera, Temuco, Chile

Correspondence should be addressed to Nilton Alves; lc.aretnorfu@sevla.notlin

Received 22 March 2017; Revised 8 July 2017; Accepted 10 August 2017; Published 27 September 2017

Academic Editor: Vahid Rakhshan

Copyright © 2017 Naira Figueiredo Deana et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. To assess the effectiveness of low-level laser therapy (LLLT) in reducing orthodontic pain after the application of orthodontic force (OF). Methods. A systematic search was conducted in the MEDLINE, EMBASE, Scopus, Cochrane Library, Web of Science, and EBSCOhost databases. The study included randomized clinical trials (RCT) which analysed the effectiveness of LLLT in reducing orthodontic pain assessed at 24 and 72 hrs after the application of OF. The risk of bias of the eligible trials was assessed using the Cochrane Collaboration’s risk of bias tool. Standard mean difference was calculated and pooled by meta-analysis using random effect models. Results. Of 467 identified articles, 20 RCT were finally included. In the risk of bias assessments, 13 studies presented a high risk, 5 an unclear risk, and 2 a low risk. The meta-analysis showed that in patients treated with laser versus placebo there was a difference in favour of LLLT in spontaneous pain 24 and 72 hrs after the installation of light archwires and spontaneous pain and chewing pain 24 and 72 hrs after the installation of elastomeric separators. Conclusions. LLLT proved to be effective in promoting a reduction in spontaneous and chewing pain after the application of OF; however, the poor quality of the evidence requires these results to be treated with caution.