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Pain Research and Management
Volume 2018, Article ID 1924174, 9 pages
Research Article

Sensory Function and Chronic Pain in Multiple Sclerosis

1Department of Clinical Neuropsychology, Vrije Universiteit, Amsterdam, Netherlands
2Department of Neuropsychology, Reade, Amsterdam, Netherlands
3Acibadem International Medical Center, Amsterdam, Netherlands

Correspondence should be addressed to Erik J. A. Scherder; ln.uv@redrehcs.a.j.e

Received 21 December 2017; Revised 6 March 2018; Accepted 22 March 2018; Published 23 April 2018

Academic Editor: Anna Maria Aloisi

Copyright © 2018 Rogier J. Scherder et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To examine whether hypoesthesia and chronic pain are related in patients with MS. Methods. Sixty-seven MS patients with pain and 80 persons without MS were included. Sensory functioning was tested by bedside neurological examination. Touch, joint position (dorsal column-medial lemniscus pathway), temperature sense, and pain (spinothalamic tract) were tested. Pain intensity was measured by the Colored Analogue Scale (CAS Intensity) and the Faces Pain Scale (FPS); pain affect was also measured by CAS Affect and Number of Words Chosen-Affective (NWC-A). Mood was assessed with the SCL-90 anxiety and depression subscales and the Beck Depression Inventory (BDI). Results. A significant negative relationship was found between pain intensity and the function of the dorsal column-medial lemniscal pathway, but not with the spinothalamic tract. Conclusion. In addition to the already known relation between hyperesthesia and pain, hypoesthesia for touch and joint position also seems to be related to chronic pain in MS patients.