Pain Research and Management / 2018 / Article / Tab 1

Review Article

Targeting the Endocannabinoid System for Prevention or Treatment of Chemotherapy-Induced Neuropathic Pain: Studies in Animal Models

Table 1

Expression of endocannabinoids in animal models of CINP.

CINP modelExpression of endocannabinoidsReference
Chemotherapy drugAnimalsCINP symptomTissueChange in endocannabinoid levels relative to control

CisplatinMale C3H/HeN miceMechanical and heat hyperalgesiaPlantar paw skinDecrease in AEA but no change in 2-AG[25]
CisplatinMale SD ratsMechanical and cold allodyniaLumbar spinal cordBoth 2-AG and AEA increased[24]
Dorsal hind paw skin2-AG decreased but not AEA
CisplatinMale C3H/HeN miceMechanical hyperalgesiaPlantar paw skinBoth 2-AG and AEA decreased[26]
DRGsBoth 2-AG and AEA decreased
Lumbar spinal cordBoth 2-AG and AEA increased
MidbrainNo effect on both 2-AG and AEA
CisplatinMale C3H/HeJ miceMechanical allodyniaPlantar paw skinDecrease in AEA but no change in 2-AG[27]

2-AG, 2-arachidonoylglycerol; AEA, N-arachidonoylethanolamine (anandamide); SD, Sprague-Dawley.