Research Article
Intranasal Pharmacokinetics of Morphine ARER, a Novel Abuse-Deterrent Formulation: Results from a Randomized, Double-Blind, Four-Way Crossover Study in Nondependent, Opioid-Experienced Subjects
Figure 4
Average time-curve plot of AUE (0-1 h, 0–2 h, 0–8 h, 0–12 h, and 0–24 h) for drug-liking VAS versus (a) Cmax, (b) Tmax, (c) AQ, and (d) AUC (0-1 h, 0–2 h, 0–8 h, 0–12 h, and 0–24 h) (PD population, ). AQ = abuse quotient, AUE = area under the drug-liking curve, AUC = area under the plasma concentration-time curve, Cmax = maximum observed plasma concentration, h = hour, Tmax = time to Cmax, and VAS = visual analog scale.
| (a) |
| (b) |
| (c) |
| (d) |