Water-Soluble Polymer Assists <i>N</i>-Methyl-D-Aspartic Acid Receptor 2B siRNA Delivery to Relieve Chronic Inflammatory Pain In Vitro and In Vivo

<div>Complex formation of WSLP/siRNA. (a) Determination of siRNA in WSPL/siRNA complexes in different weight ratios by using 20% PAGE gel. Lanes 1–8: naked siRNA, 1 : 1, 2 : 1, 3 : 1, 4 : 1, 5 : 1, 6 : 1, and 7 : 1, respectively. (b) The stability of WSPL/siRNA complex of 2 : 1 in serum. (c) NR2B mRNA expression was tested by qRT-PCR as normalized to <i>β</i>-actin. (d) NR2B protein expression was analyzed by WB.</div>

Pain Research and Management

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Figure 1

Figure 1: Water-Soluble Polymer Assists <i>N</i>-Methyl-D-Aspartic Acid Receptor 2B siRNA Delivery to Relieve Chronic Inflammatory Pain In Vitro and In Vivo 

Figure 1 | Water-Soluble Polymer Assists N-Methyl-D-Aspartic Acid Receptor 2B siRNA Delivery to Relieve Chronic Inflammatory Pain In Vitro and In Vivo 