Antinociceptive Activity of Methanolic Extract of Clinacanthus nutans Leaves: Possible Mechanisms of Action Involved

Figure 5

The involvement of various nonopioid receptor antagonists on MECN-induced antinociception in the acetic acid-induced abdominal constriction test in mice. Yohimbine (YOH; 0.15 mg/kg, i.p.), pindolol (PDL; 1 mg/kg, i.p.), caffeine (CAF; 3 mg/kg, i.p.), and haloperidol (HAL; 0.2 mg/kg; i.p.) were administrated 15 min before vehicle (10 mL/kg, p.o.) or MECN (500 mg/kg, p.o.). Each column represents the mean ± SEM of six mice. Statistical analyses were performed using 1-way ANOVA followed by Dunnett’s post hoc test. compared to the control group. ^# and ^### compared to 500 mg/kg MECN-treated group.