Antinociceptive Activity of Methanolic Extract of Clinacanthus nutans Leaves: Possible Mechanisms of Action Involved

Table 2

Several volatile bioactive compounds with reported antinociceptive activity that has been previously identified in MECN using the GCMS procedure.

Number	Flavonoid-based bioactive compounds	Antinociceptive model used	Antinociceptive activity reported by
(1)	9,12,15-octadecatrienoic acid (α-linolenic acid)	(i) Acetic acid-induced writhing test	Ren and Chung [29]
		(ii) Randal–Selitto assay
(2)	Phytol	(i) Acetic acid-induced writhing test	Santos et al. [30]
		(ii) Formalin-induced paw licking test
		(iii) Hot plate test
(3)	n-hexadecanoic acid	(i) Neuropathic pain model	Aparna et al. [31]
		(ii) CCI-induced neuropathic pain test
		(iii) Mechanical allodynia test
		(iv) Thermal hyperalgesia
		(v) Electronic von Frey test
		(vi) Hot plate test