Pain Research and Management / 2018 / Article / Tab 2

Research Article

Antinociceptive Activity of Methanolic Extract of Clinacanthus nutans Leaves: Possible Mechanisms of Action Involved

Table 2

Several volatile bioactive compounds with reported antinociceptive activity that has been previously identified in MECN using the GCMS procedure.

NumberFlavonoid-based bioactive compoundsAntinociceptive model usedAntinociceptive activity reported by

(1)9,12,15-octadecatrienoic acid (α-linolenic acid)(i) Acetic acid-induced writhing testRen and Chung [29]
(ii) Randal–Selitto assay

(2)Phytol(i) Acetic acid-induced writhing testSantos et al. [30]
(ii) Formalin-induced paw licking test
(iii) Hot plate test

(3)n-hexadecanoic acid(i) Neuropathic pain modelAparna et al. [31]
(ii) CCI-induced neuropathic pain test
(iii) Mechanical allodynia test
(iv) Thermal hyperalgesia
(v) Electronic von Frey test
(vi) Hot plate test

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