Antiallodynic Effects of Cannabinoid Receptor 2 (CB₂R) Agonists on Retrovirus Infection-Induced Neuropathic Pain

Figure 1

Acute antiallodynic effects of CB₂R agonists on retrovirus-infected animals. (a) C57BL/6 mice were randomly assigned into uninfected (UI) or LP-BM5-infected (IF) groups (/group), and hind-paw mechanical hypersensitivity was assessed weekly via the MouseMet electronic von Frey system between 5 and 12 wk p.i. Following LP-BM5 infection, synthetic CB₂R ligands were injected (5 mg/kg, i.p.) once/wk starting at 5 wk·p.i. (red arrow). Assessment of allodynia was performed weekly 2 h after injection of the indicated ligand: (b) JWH015; (c) JWH133; (d) Gp1a; (e) HU308. Data are presented as the mean ± SE paw withdrawal threshold with /group. and vs. corresponding paw/wk p.i. (ANOVA with Fisher’s LSD post hoc analysis).

(a)

(b)

(c)

(d)

(e)