Pain Research and Management / 2019 / Article / Tab 6

Review Article

An Overview of Systematic Reviews of Randomized Controlled Trials on Acupuncture Treating Migraine

Table 6

MAs outcomes about efficacy.

Study IDOutcomeAcute or preventive treatmentInterventionControlFollow-up timeRCTs (n)I2ModelScaleEffect95% CIP value

Linde et al. [14]Response (attack frequency reduction of at least 50%)NDAcupuncture3-4 months after randomization4 (2376)0%REMRR2.33[2.02, 2.69]<0.00001
2 months after randomization7 (1091)59%REMRR1.38[0.96, 1.97]0.08
3-4 months after randomization11 (1225)14%REMRR1.13[0.95, 1.35]0.16
5-6 months after randomization6 (1054)64%REMRR1.19[0.86, 1.63]0.29
>6 months after randomization3 (132)10%REMRR1.01[0.51, 1.99]0.98
2 months after randomization2 (566)0%REMRR1.35[1.09, 1.67]0.006
3-4 months after randomization2 (566)0%REMRR1.20[0.98, 1.46]0.08
5-6 months after randomization2 (564)62%REMRR1.35[0.89, 2.05]0.16

Linde et al. [7]Response (at least 50% frequency reduction)Preventive treatmentAcupunctureMedian 3 months4 (2519)7%FEMRR2.40[2.08, 2.76]<0.00001
Median 3 months14 (1825)48%FEMRR1.23[1.11, 1.36]<0.00001
Median 12 months11 (1683)61%FEMRR1.25[1.13, 1.39]<0.00001
Median 3 months3 (743)0%FEMRR1.24[1.08, 1.44]0.003
Median 12 months3 (744)0%FEMRR1.11[0.97, 1.26]0.12

Chen et al. [15]Effective rate (headache relieved or disappeared)NRAcupunctureND18 (1730)0%FEMOR5.11[3.81, 6.85]<0.00001

Chen [16]Effective rate (headache controlled or disappeared)NRAcupunctureND18 (1606)42%FEMRR1.21[1.16, 1.27]<0.00001

Chu et al. [17]Effective rate (ND)NRAcupunctureND2 (139)0%FEMOR5.70[1.88, 17.27]0.002
ND20 (2096)13%FEMOR3.96[3.02, 5.19]<0.00001
TCM drug treatmentND2 (162)0%FEMOR7.58[2.30, 24.92]0.0009

Dai and Lin [19]Cure rate (ND)NRAcupunctureND2 (140)0%FEMOR3.02[1.00, 9.07]0.05
Response rate (include cure rate)NRND2 (140)0%FEMOR5.37[2.57, 11.21]<0.00001
Effective rate (cure and response rates)NRND2 (140)0%FEMOR4.85[1.69, 13.94]0.003
Gao et al. [20]Effective rate (at least 50% frequency reduction)NRAcupunctureND8 (1253)0%FEMOR1.28[1.02, 1.61]0.03

Zheng and Hai [22]Effective rate (ND)NRAcupunctureND3 (217)69%REMRR1.87[1.17, 2.98]0.009
ND28 (3059)81%REMRR1.24[1.16, 1.33]<0.00001
TCM drug treatmentND3 (225)0%FEMRR1.29[1.14, 1.45]<0.00001

Zhao [23]Effective rate (ND)NRAcupunctureND8 (686)50%REMRR1.19[1.07, 1.32]0.0010
Acupuncture with acupuncture on ear3 months2 (152)0%FEMRR1.18[1.05, 1.33]0.005
Acupuncture with TCM drug treatmentAt least 6 months3 (257)98%REMRR1.24[0.61, 2.52]0.0009

Pu [24]Effective rate (at least 50% frequency reduction)Preventive treatmentAcupuncture3-4 months after randomization4 (772)57%REMRR1.41[1.06, 1.88]0.02
5-6 months after randomization2 (564)0%FEMRR1.18[0.97, 1.43]0.11

Song et al. [26]Effective rate (ND)Preventive treatmentAcupuncture1-3 months15 (1218)35%FEMOR2.76[2.03, 3.77]<0.00001
>3 months7 (642)0%FEMOR4.17[2.80, 6.20]<0.00001

Yang et al. [27]EfficacyNRAcupunctureShort-term (ND)9 (821)69%REMRR1.27[1.11, 1.45]0.0004
Long-term (ND)4 (232)87%REMRR1.76[1.05, 2.94]0.03

NR: not reported; ND: not defined; ①: no acupuncture; ②: sham acupuncture; ③: drug treatment; FEM: fixed effects model; REM: random effects model.

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