Microglial BDNF, PI3K, and p-ERK in the Spinal Cord Are Suppressed by Pulsed Radiofrequency on Dorsal Root Ganglion to Ease SNI-Induced Neuropathic Pain in Rats

Figure 1

Therapeutic effects of minocycline on neuropathic pain in SNI rats. (a, b) Effects of minocycline (a specific inhibitor of microglial activation) on mechanical allodynia and thermal hyperalgesia. Reversal of SNI-induced allodynia by intrathecal administration of minocycline once a day for 7 days (1 h before nerve ligation) in the rats. All rats (except those in the Sham group) were subjected to SNI of the right sciatic nerve. The rats in the SNI + M and SNI + DMSO groups were intrathecally treated with minocycline and an equal volume of DMSO, respectively. Each symbol represents mean ± SEM; against the Sham group and against the SNI group. Repeated-measures (multiple groups × time) ANOVA, n = 15 per group. (c, d) Changes in paw withdrawal threshold and paw withdrawal latency in contralateral hind paw of all groups.

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