Pain Research and Management / 2019 / Article / Fig 6

Research Article

Microglial BDNF, PI3K, and p-ERK in the Spinal Cord Are Suppressed by Pulsed Radiofrequency on Dorsal Root Ganglion to Ease SNI-Induced Neuropathic Pain in Rats

Figure 6

Therapeutic effects of PRF on DRG on neuropathic pain. (a, b) Effects of PRF on mechanical allodynia and thermal hyperalgesia applied to L4-L5 DRG. The paw withdrawal threshold in response to mechanical hypersensitivity (a) and paw withdrawal latency in response to thermal hyperalgesia (b) partially recovered from the first day after a single application of PRF and maintained throughout a period of 14 days. On postoperative day 7, PRF was applied to the ipsilateral L4-L5 DRG in the SNI + PRF group, and SNI + free-PRF group was kept as control. Each symbol represents mean ± SEM; against the Sham group and against the SNI group. Repeated-measures (multiple groups × time) ANOVA, n = 15 per group. (c, d) Changes in paw withdrawal threshold and paw withdrawal latency in contralateral hind paw of all groups.

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.