Microglial BDNF, PI3K, and p-ERK in the Spinal Cord Are Suppressed by Pulsed Radiofrequency on Dorsal Root Ganglion to Ease SNI-Induced Neuropathic Pain in Rats

Figure 6

Therapeutic effects of PRF on DRG on neuropathic pain. (a, b) Effects of PRF on mechanical allodynia and thermal hyperalgesia applied to L₄-L₅ DRG. The paw withdrawal threshold in response to mechanical hypersensitivity (a) and paw withdrawal latency in response to thermal hyperalgesia (b) partially recovered from the first day after a single application of PRF and maintained throughout a period of 14 days. On postoperative day 7, PRF was applied to the ipsilateral L₄-L₅ DRG in the SNI + PRF group, and SNI + free-PRF group was kept as control. Each symbol represents mean ± SEM; against the Sham group and against the SNI group. Repeated-measures (multiple groups × time) ANOVA, n = 15 per group. (c, d) Changes in paw withdrawal threshold and paw withdrawal latency in contralateral hind paw of all groups.

(a)

(b)

(c)

(d)