Reward Processing under Chronic Pain from the Perspective of “Liking” and “Wanting”: A Narrative Review

Table 2

Reward-related behaviors in animals with chronic pain.

Study	Species	Reward stimuli	Pain model	Test (results)
Dellarole et al. [49]	Mouse	SW	CCI	SPT (decrease)
Wang et al. [50]	Rat	SW	SNI	SPT (decrease)
Wu et al. [51]	Mouse	SW	SNI	SPT (decrease)
Bura et al., 2013	Mouse	SW	PSNL	SPT (decrease)
Amorim et al. [52]	Rat	SW	Arthritis	SPT (decrease)
Liu et al. [53]	Rat	SW	Fibromyalgia	SPT (decrease)
Shi et al. [54]	Rat	SW	SNL	SPT (no change)
Shi et al. [55]	Rat	SW	CFA	SPT (no change)
Su et al. [56]	Rat	SW	SNI; CFA	SPT (decrease)
Urban et al. [57]	Mouse	SW; food; water	SNI; CCI; CFA	SPT (no change); food intake (no change); water intake (no change)
Bravo et al. [58]	Rat	Cereals	CCI	Food intake (no change)
Goffer et al. [59]	Rat	SW; water	SNI	SPT (decrease); water intake (no change)
Okun et al. [60]	Rat	Food	CFA, SNL	SA with PR (CFA decrease, SNL no change); SA with FR (no change); tasty reactivity (no change)
Schwartz et al. [61]	Mouse	SW; food	CFA; SNI	SPT (no change); SA with PR (decrease); SA with FR (no change); food intake (no change)
Hipólito et al. [62]	Rat	SW	CFA	SA with PR (decrease); SA with FR (no change)
Schwartz et al. [63]	Rat	SW	SNI	AAT (decrease)

Abbreviations: SW, sucrose-containing water; SNI, spinal nerve injury; SPT, sucrose preference test; CCI, chronic constriction injury; CFA, complete Freund’s adjuvant injection; SNL, spinal nerve ligation; SA, self-administration; PR, progressive ratio protocol; FR, fixed ratio protocol; PSNL, partial ligation of the sciatic nerve; AAT, avoidance-reward approach task.