Table 2: Reward-related behaviors in animals with chronic pain.

StudySpeciesReward stimuliPain modelTest (results)

Dellarole et al. [49]MouseSWCCISPT (decrease)
Wang et al. [50]RatSWSNISPT (decrease)
Wu et al. [51]MouseSWSNISPT (decrease)
Bura et al., 2013MouseSWPSNLSPT (decrease)
Amorim et al. [52]RatSWArthritisSPT (decrease)
Liu et al. [53]RatSWFibromyalgiaSPT (decrease)
Shi et al. [54]RatSWSNLSPT (no change)
Shi et al. [55]RatSWCFASPT (no change)
Su et al. [56]RatSWSNI; CFASPT (decrease)
Urban et al. [57]MouseSW; food; waterSNI; CCI; CFASPT (no change); food intake (no change); water intake (no change)
Bravo et al. [58]RatCerealsCCIFood intake (no change)
Goffer et al. [59]RatSW; waterSNISPT (decrease); water intake (no change)
Okun et al. [60]RatFoodCFA, SNLSA with PR (CFA decrease, SNL no change); SA with FR (no change); tasty reactivity (no change)
Schwartz et al. [61]MouseSW; foodCFA; SNISPT (no change); SA with PR (decrease); SA with FR (no change); food intake (no change)
Hipólito et al. [62]RatSWCFASA with PR (decrease); SA with FR (no change)
Schwartz et al. [63]RatSWSNIAAT (decrease)

Abbreviations: SW, sucrose-containing water; SNI, spinal nerve injury; SPT, sucrose preference test; CCI, chronic constriction injury; CFA, complete Freund’s adjuvant injection; SNL, spinal nerve ligation; SA, self-administration; PR, progressive ratio protocol; FR, fixed ratio protocol; PSNL, partial ligation of the sciatic nerve; AAT, avoidance-reward approach task.