Role of p120 Catenin in Epac1-Induced Chronic Postsurgical Pain in Rats

Figure 2

CPSP was correlated with the continuous increase of the vascular endothelial permeability and the distribution of macrophages and endothelial cells around the incision. (a) The intravascular Evan extravasation of the SMIR group was significantly increased after surgery, vs. naive group. In the SMIR group, the intravascular Evan extravasation on the 3rd day increased significantly, while it decreased significantly on the 14th day; in the Sham group also, it decreased ( vs. the 7th day). (b) The wall of the fine and small blood vessels in the SMIR and sham groups was ruptured and incomplete, the distribution of red blood cells in the intravascular density narrowed, and the distribution of red cells increased in the interstitial space. (c) Endothelial cells increased significantly on the 3rd, 7th, and 14th day in the SMIR group, vs. naive group. (d) Macrophages increased significantly in the sham group and the 3rd, 7th, and 14th day in the SMIR group, , vs. naive group. Data information in (a, c, d): error bars indicate SEM derived from at least three independent experiments, and significance was calculated by one-way analysis of variance ().

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