Role of p120 Catenin in Epac1-Induced Chronic Postsurgical Pain in Rats

Figure 6

Effects of CE3F4 on changes of MWT, vascular endothelial permeability, macrophages, endothelial cells, the expression of p120 by CPSP in muscle tissue around the incision. (a) MWT at the 1st, 3rd, 6th, 12th and 24th hour in SMIR + CE3F4 group was significantly higher, , vs. SMIR + saline group. (b) Evan’s exudation was significantly reduced at the 3rd and 6th hour in SMIR + CE3F4 group, vs. SMIR + saline group. (c) The expression of p120 at the 3rd and 6th hour in SMIR + CE3F4 group was significantly increased, , vs. SMIR + saline group. (d) Endothelial cells were significantly decreased at the 3rd and 6th hour in SMIR + CE3F4 group, , vs. SMIR + saline group. (e) Macrophages were significantly reduced at 6th hour in SMIR + CE3F4 group, vs. SMIR + saline group. Data information: (a–e) error bars indicate SEM derived from at least three independent experiments, (a) significance was calculated by 2-way analysis of variance (ANOVA) followed by the Bonferroni test, and (b–e) significance was calculated by one-way analysis of variance ().

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