SIRT1 Mediates Neuropathic Pain Induced by Sciatic Nerve Chronic Constrictive Injury in the VTA-NAc Pathway

Figure 1

Experimental schedule. One day before the surgery, behavioral testing was performed to eliminate the mice exhibiting hyperalgesia or dysesthesia to pain. 12 days after the surgery, the CCI mice exhibiting hyperalgesia were microinjected with SRT1720, EX-527, or vehicle. 12 h after the microinjection, the effect of SRT1720 and EX-527 on neuropathic pain was indicated by behavioral testing.