SIRT1 Mediates Neuropathic Pain Induced by Sciatic Nerve Chronic Constrictive Injury in the VTA-NAc Pathway

<div>Localization of SIRT1 in the VTA of mice. Double immunofluorescent staining for SIRT1 (red) and NeuN (green), GFAP (green), or Iba-1 (green) was employed to identify the location of SIRT1 in the VTA. The nucleus was counterstained with DAPI (blue). Colocalization of SIRT1 and NeuN denotes that SIRT1 localizes in the nuclei of the neurons (white arrows). Scale bar = 50 <i>μ</i>m. (a) SIRT1/NeuN. (b) SIRT1/GFAP. (c) SIRT1/Iba-1.</div>

Pain Research and Management

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Figure 2

Figure 2: SIRT1 Mediates Neuropathic Pain Induced by Sciatic Nerve Chronic Constrictive Injury in the VTA-NAc Pathway 