Progesterone Attenuates Allodynia of Inflamed Temporomandibular Joint through Modulating Voltage-Gated Sodium Channel 1.7 in Trigeminal Ganglion
Progesterone attenuated sodium currents in freshly isolated TG neurons. (a) Representative traces showing that extracellular application of progesterone (P4, 50 µM) decreases sodium currents after 5 min reversibly in freshly isolated TG neurons in response to 50 ms depolarization from −80 mV to 30 mV from an holding potential of −100 mV with an increment of 5 mV every 5 s. (b) Statistical data showing that 5 min treatment with P4 (50 µM) attenuate the peak value of sodium currents (n = 6) in freshly isolated TG neurons. versus the control group. (c) The voltage-dependent activation curve of sodium channels in TG neurons before and after P4 application. (d) The steady-state inactivation curve of sodium channels in TG neurons before and after P4 application.
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