Progesterone Attenuates Allodynia of Inflamed Temporomandibular Joint through Modulating Voltage-Gated Sodium Channel 1.7 in Trigeminal Ganglion

Figure 3

Progesterone attenuated sodium currents in freshly isolated TG neurons. (a) Representative traces showing that extracellular application of progesterone (P4, 50 µM) decreases sodium currents after 5 min reversibly in freshly isolated TG neurons in response to 50 ms depolarization from −80 mV to 30 mV from an holding potential of −100 mV with an increment of 5 mV every 5 s. (b) Statistical data showing that 5 min treatment with P4 (50 µM) attenuate the peak value of sodium currents (n = 6) in freshly isolated TG neurons. versus the control group. (c) The voltage-dependent activation curve of sodium channels in TG neurons before and after P4 application. (d) The steady-state inactivation curve of sodium channels in TG neurons before and after P4 application.

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