Progesterone Attenuates Allodynia of Inflamed Temporomandibular Joint through Modulating Voltage-Gated Sodium Channel 1.7 in Trigeminal Ganglion

<div>A model diagram of progesterone attenuating allodynia of inflamed temporomandibular joint (TMJ) through modulating voltage-gated sodium channel 1.7 in trigeminal ganglion. TMJ inflammation induces expressions of cytokines, such as TNF<i>α</i>, IL-1<i>β</i>, and NGF. These cytokines will act on the nerve endings, initiate impulse, and induce Nav1.7 expression in the TG. P4 may downregulate trigeminal ganglionic Nav1.7 expressions, which reduce the stimuli in the neurons, through progesterone receptors (PR<i>α</i>/<i>β</i>), and then attenuates allodynia of inflammatory TMJ.</div>

Pain Research and Management

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Figure 5: Progesterone Attenuates Allodynia of Inflamed Temporomandibular Joint through Modulating Voltage-Gated Sodium Channel 1.7 in Trigeminal Ganglion 

Figure 5 | Progesterone Attenuates Allodynia of Inflamed Temporomandibular Joint through Modulating Voltage-Gated Sodium Channel 1.7 in Trigeminal Ganglion 