Pain Research and Management

Review Article

How to Choose Platelet-Rich Plasma or Hyaluronic Acid for the Treatment of Knee Osteoarthritis in Overweight or Obese Patients: A Meta-Analysis

Table 1

Characteristics of all the trials included in the meta-analysis.


Authors	Country	Study type	Sample size	Mean BMI (kg/m²)	Mean age (years)	Gender	Radiographic classification		Intervention	Follow-up (mo)
			PRP : HA	PRP : HA	PRP : HA	M : F	K-L (I/II/III/IV)	Ahlbäck (I/II/III)

Sánchez et al. [11]	Spain	RCTs	176 (89/87)	27.9/28.2	60.5/58.9	85/91	NP^†	45/32/12 (PRP)^†	3 times, 8 mL, weekly^†	1, 2, 6
							NP^‡	42/32/11 (HA)^‡	3 times, weekly^‡

Vaquerizo et al. [12]	Spain	RCTs	96 (48/48)	30.7/31.0	62.4/64.8	38/58	2.6 (mean score)^†	NP^†	3 times, 8 mL, every 2 weeks^†	6, 12
							2.8 (mean score)^‡	NP^‡	1 time, 60 mg/3 mL^‡

Raeissadat et al. [14]	Iran	RCTs	139 (77/62)	28.20/27.03	56.85/61.13	23/116	5/34/29/9^†	NP^†	2 times, 5 mL, monthly^†	1, 6, 12
							0/29/23/10^‡	NP^‡	3 times, 20 mg/2 mL, 500 to 730 kDa, monthly^‡

Filardo et al. [13]	Italy	RCTs	193 (94/89)	26.6/26.9	53.32/57.55	112/71	2.0 (mean score)^†	NP^†	3 times, 5 mL, weekly^†	2, 6, 12
							2.0 (mean score)^‡	NP^‡	3 times, 30 mg/2 mL, >1,500 kDa, weekly^‡

Paterson et al. [15]	Australia	RCTs	21 (11/10)	27.92/30.87	49.91/52.70	15/6	0/11 (II-III)/0^†	NP^†	3 times, 3 ml^†	1, 3
							0/10 (II-III)/0^‡	NP^‡	3 times, 3 mL^‡

Duymus et al. [16]	Turkey	RCTs	67 (33/34)	27.6/28.4	60.4/60.3	2/65	0/22/11/0^†	NP^†	2 times, 5 mL per time, every 2 weeks^†	1, 3, 6, 12
							0/24/10/0^‡	NP^‡	40 mg/2 mL, 1,600 kDa^‡

Görmeli et al. [17]	Turkey	RCTs	83 (44/39)	28.4/29.7	53.8/53.5	36/47	0/30 (II-III)/14^†	NP^†	1 time, 5 mL, weekly^†	6
							0/25 (II-III)/14^‡	NP^‡	3 times, 30 mg/2 mL^‡

Cole et al. [5]	USA	RCTs	99 (49/50)	27.4/29.0	55.9/56.8	48/51	3/26/20/0^†	NP^†	3 times, 4 mL, weekly^†	1, 3, 6, 12
							0/27/22/0^‡	NP^‡	3 times, 16 mg/2 mL, 6,000 kDa^‡

Di Martino et al. [18]	Italy	RCTs	167 (85/82)	27.2/26.8	52.7/57.5	100/67	2.0 (mean score)^†	NP^†	3 times, 5 mL, weekly^†	2, 6, 12, 24
							2.0 (mean score)^‡	NP^‡	3 times, 30 mg/2 mL, >1,500 kDa, weekly^‡

Su et al. [19]	China	RCTs	55 (25/30)	28.17/28.69	54.16/53.13	23/32	0/13/12/0^†	NP^†	2 times, 6 ml, every 2 weeks^†	1, 3, 6, 12, 18
							0/14/16/0^‡	NP^‡	2 times, 20 mg/2 mL, once a week^‡

^†PRP group, ^‡HA group. PRP: platelet-rich plasma; HA: hyaluronic acid; K-L: Kellgren and Lawrence grading scale; NP: not provided.