How to Choose Platelet-Rich Plasma or Hyaluronic Acid for the Treatment of Knee Osteoarthritis in Overweight or Obese Patients: A Meta-Analysis

Table 2

Outcomes of the meta-analysis in different follow-up months.

Follow-up	Evaluation tools	Number of studies	Patients PRP : HA	MD	95% CI		I^2 (%)
1 months	VAS	3	69/74	0.01	[−0.13, 0.15]	No	0
	WOMAC total score	2	58/64	−3.33	[−8.84, 2.18]	No	78
	WOMAC pain score	3	107/114	0.01	[−0.47, 0.50]	No	16
	WOMAC stiffness score	2	58/64	−0.11	[−0.47, 0.24]	No	35
	WOMAC physical function score	2	58/64	−2.35	[−5.28, 0.57]	No	59
2 months	EQ-VAS	2	179/171	2.15	[−0.57, 4.88]	No	0
	IKDC	2	179/171	−0.59	[−3.90, 2.72]	No	0
3 months	VAS	3	68/73	−0.20	[−0.71, 0.31]	No	72
	WOMAC total score	2	58/64	−1.35	[−2.19, −0.50]	Yes	0
	WOMAC pain score	3	107/114	0.05	[−0.31, 0.41]	No	0
	WOMAC stiffness score	2	58/64	−0.38	[−0.67, −0.10]	Yes	0
	WOMAC physical function score	2	58/64	−1.92	[−2.57, −1.27]	Yes	0
6 months	VAS	3	107/114	−0.35	[−1.23, 0.54]	No	75
	EQ-VAS	3	223/210	1.89	[−0.19, 3.96]	No	0
	IKDC	3	187/178	2.23	[−0.41, 4.86]	No	10
	WOMAC total score	3	147/151	−3.89	[−5.60, −2.18]	Yes	23
		4^§	195/199^§	−7.62^§	[−13.51, −1.72]^§	Yes^§	88^§
	WOMAC pain score	4	196/201	−0.76	[−1.11, −0.42]	Yes	0
		5^§	244/249^§	−1.74^§	[−3.13, −0.36]^§	Yes^§	87^§
	WOMAC stiffness score	3	147/151	−0.41	[−0.67, −0.16]	Yes	0
		4^§	195/199^§	−0.62^§	[−1.12, −0.11]^§	Yes^§	61^§
	WOMAC physical function score	3	147/151	−1.64	[−2.36, −0.91]	Yes	0
		4^§	195/199^§	−4.23^§	[−8.58, 0.13]^§	No^§	89^§
12 months	VAS	3	107/114	−1.27	[−2.36, −0.18]	Yes	91
	EQ-VAS	2	179/171	4.64	[1.86, 7.42]	Yes	0
	IKDC	2	143/139	5.45	[−3.13, 14.03]	No	60
	WOMAC total score	3	135/126	−8.79	[−16.22, −1.35]	Yes	93
		4^§	183/168^§	−12.11^§	[−20.21, −4.01]^§	Yes^§	94^§
	WOMAC pain score	4	184/176	−1.41	[−2.43, −0.39]	Yes	82
		5^§	232/218^§	−1.95^§	[−3.18, −0.71]^§	Yes^§	89^§
	WOMAC stiffness score	3	135/126	−0.65	[−0.92, −0.39]	Yes	11
		4^§	183/168^§	−0.99^§	[−1.57, −0.42]^§	Yes^§	81^§
	WOMAC physical function score	3	135/126	−6.53	[−12.13, −0.94]	Yes	93
		4^§	183/168^§	−8.90^§	[−14.82, −2.99]^§	Yes^§	94^§

^§Include a study with BMI > 30 Kg/m².