Mannitol Enhances the Antinociceptive Effects of Diphenhydramine as an Alternative Local Anesthetic

Figure 3

Enhancement of the antinociceptive effects of diphenhydramine by mannitol. As the control group, the subcutaneous injection of 0.5 M mannitol solution alone did not affect the withdrawal latency time. However, the injection of 1% diphenhydramine combined with 0.5 M mannitol significantly enhanced antinociception compared with 1% diphenhydramine alone. The values shown are the mean ± SEM, and there were seven animals in each group. , diphenhydramine with mannitol vs. diphenhydramine without mannitol.