Pharmacokinetic Characterisation and Comparison of Bioavailability of Intranasal Fentanyl, Transmucosal, and Intravenous Administration through a Three-Way Crossover Study in 24 Healthy Volunteers

Table 6

Parametric point estimates for AUC_0-tlast after dose adjustment.

AUC0-tlast
Comparison		PE (%)	90% CI (%)		CVANOVA (%)	Power (%)
INTRANASAL	INTRAVENOUS	74.70	69.01	80.87	16.10	99.74
INTRANASAL	TRANSMUCOSAL	45.27	41.64	49.23	17.00	99.54
TRANSMUCOSAL	INTRAVENOUS	165.01	152.83	178.15	15.60	99.83
TRANSMUCOSAL	INTRAVENOUS	41.25	38.21	44.54	15.60	99.83
INTRANASAL	TRANSMUCOSAL	198.18	182.26	215.49	17.40	99.54

Dose adjusted to 50 μg fentanyl. dose adjusted to 47 μg fentanyl.