The Comparison of Short-Term Postoperative Pain in Single- versus Multiple-Visit Root Canal Treatment: A Systematic Review and Meta-Analysis Study

Table 1

The inclusion studies in systematic review and meta-analysis.

	Author	Type of study	Sample size	Age range	Irrigation	Obturation method	Pain	Vital/nonvital	Duration	Study quality
1	Singh 2020, India [18]	RCT	64	>10 years	3% NaOCl + normal saline	Unclear	Multi > one visit,	Vital	24, 48, 72 h, 1 week, 1, 3, 6, 9 months	7
2	Mogla 2020, India [19]	RCT	40	>10 years	2.5% NaOCl + normal saline	Unclear	Multi > one visit,	Vital	6, 12, 24, 48 h	5
3	Alomaym 2019, Saudi Arabia [13]	RCT	400	>18 years	2.5% NaOCl	Lateral condensation		Both of them	6, 12, 24, 48 h	5
4	Singh 2019, India [11]	RCT	60	>10 years	Unclear	Unclear	Multi > one visit,	Vital	24 h	5
5	Hebatallah et al. 2019, Egypt [20]	RCT	50	18–60 years	2.6% NaOCl	Lateral condensation		Nonvital	6, 24, 48 h 7 days	7
6	Joshi et al. 2019, India [12]	RCT	60	15–50 years	2.5% NaOCl, 17% EDTA, normal saline	Warm vertical condensation	One visit > multiple visit,	Vital	48 h, 1, 4, 6 weeks	5
7	Hepsenogl et al. 2018, Turkey [21]	RCT	150	18–75 years	2.5% NaOCl, 5% EDTA, 5 mL distilled water	Noncompaction	Multi > one visit,	Vital	1, 2, 3, 7, and 30 days	4
8	EL Sheikh 2017, Egypt [22]	RCT	50	15–40 years	2.5% NaOCl and 17% EDTA	Lateral condensation		Vital	24 h, 7 d, 1 month	7
9	Patil et al. 2016, India [23]	RCT	65	15–50 years	2.5% NaOCl, normal saline	Lateral condensation	Multi > one visit,	Both of them	6, 12, 24, 48 h	8
10	Wong et al. 2015, China [24]	RCT	538	Age mean 46.38	5.25% NaOCl	Core-carrier		Both of them	24 h, 1 week	7
11	Keskin 2015, Turkey [25]	RCT	188	>18 years	5.25% NaOCl, 17% EDTA	Lateral condensation		Both of them	24, 48, 72 h	8
12	Rao 2014, India [26]	RCT	148	18–50	2.5% NaOCl, saline	Lateral condensation		Vital	6, 24, 48 h, 7 days	7
13	Singh and Garg 2012, India [27]	RCT	188	20–60 years	2.5% NaOCl	Lateral condensation		Both of them	6, 12, 24, 48 h, 7 days	7
14	Prashanth et al. 2011, India [28]	RCT	32	>10 years	2.5% NaOCl, EDTA 17%	Warm vertical condensation		Vital	48 h. 14, 6 weeks	4
15	Wang et al. 2010, China [29]	RCT	89	20–60 years	2.5% NaOCl	Lateral condensation		Vital	6, 24, 48 h, 1 week	5
16	Ince et al. 2009, Turkey [30]	RCT	306	18–60 years	5% NaOCl	Lateral condensation		Both of them	1 week	7
17	Risso et al. 2008, Brazil [31]	RCT	121	11–18 years	5.25% NaOCl, +5% sodium thiosulfate (Na2S2O3)	Lateral condensation		Vital	6, 12, 24 h, 9 days	8
18	Gesi et al. 2006, Sweden [32]	RCT	244	>10 years	3% NaOCl	Lateral condensation		Vital	1 week	7
19	Al-Negrish and Habahbeh 2006, Jordan [16]	RCT	112	15–45 years	NaOCl	Lateral condensation		Nonvital	2, 7 days	5
20	Ghodosi et al. 2006, Iran [33]	RCT	60	>18 years	Normal saline	Lateral condensation		Nonvital	Every 6 hours for 72 h	5
21	Oginni and Udoye 2004, Nigeria [34]	RCT	225	>10 years	Unclear	Lateral compaction	One visit > multiple visit, .	Vital	1, 7, 30 days	7
22	Yoldas, et al. 2004, Turkey [35]	RCT	218	>18 years	2.5% NaOCl	Lateral compaction.	One visit > multiple visit,	Vital	1 week	5
23	DiRenzo et al. 2002, USA [36]	RCT	72	>18 years	2.5% NaOCl	Lateral condensation		Both of them	6, 12, 24, 48 h	5
24	Al-bashaireh and Alnegrish 1998, Jordan [37]	RCT	291	>15 years	2.6% NaOCl	Lateral condensation	Multi > one visit,	Nonvital	24 h	7
25	Fava 1989, Brazil [38]	RCT	60	>12 years	1% NaOCl	Lateral condensation		Nonvital	48 h, 1 week	5
26	Roane et al. 1983, USA [39]	RCT	359	>18 years	5.25% NaOCl	Warm vertical condensation	Multi > one visit,	Vital	24 h	5
27	Soltanoff 1978, USA [40]	RCT	282	>18 years	2.5% NaOCl	Lateral compaction.	One visit > multivisit,	Vital	48 h	5