Pain Research and Management / 2021 / Article / Tab 1

Review Article

Acupuncture for Chronic Pain-Related Depression: A Systematic Review and Meta-Analysis

Table 1

Characteristics of included studies.

StudySample sizeMean age (SD)Sex (male/female)DiagnosisInterventions’ groupControl groupTreatment periodOutcomes

Huang and Luo [28]6530.39 ± 7.0125/40Depression: CCMD-2-R
CP : CD
EAMedicine (amitriptyline)T: once a day, six times per week for 6 weeks, 20 min
C: once a day for 6 weeks
HAMD, AE

Cao et al. [29]60NR23/37CDMAMedicine (Deanxit)T: once a day, five times per week for 4 weeks, 30 min
C: twice a day for the first 10 days and once a day for the next 18 days for 4 weeks
HAMD, VAS, AE

Liu et al. [30]90T: 47 ± 8
C: 48 ± 8
T: 15/30
C: 16/29
Depression: CCMD-3
CP : CD
MA + CMedicine (SSRI antidepressants)T: once every two days for 4 weeks, 30 min; drug treatment was the same as the control group
C: once a day for 4 weeks
HAMD, VAS

Zhao et al. [31]60NRT: 12/18
C: 11/19
Depression: CD
CP : ICHD
MA + CMedicine (diclofenac sodium)T: twice a day, 6 times a week for 30 days, 30 minutes; drug treatment was the same as the control group
C: once a day for 30 days
HAMD

Ma et al. [32]128T: 39.93 ± 12.93 
C: 38.69 ± 14.19
T: 27/37
C: 29/35
Depression: ICD-10
CP : CD
MA + CMedicine (duloxetine + benzodiazepines)T: five times per week for 8 weeks, 20 min; drug treatment was the same as the control group
C: duloxetine once a day for 8 weeks, benzodiazepines were used according to the needs of the disease
HAMD, VAS, AE

Yu et al. [33]40T: 41 ± 8
C: 40 ± 7
T: 6/14
C: 8/12
Depression: CD
CP : CCMD-3
MAMedicine (Deanxit)T: once a day, six times a week for 8 weeks, 50 min
: twice a day for 8 weeks
HAMD, VAS, AE

Luo et al. [34]84T: 57.15 ± 11.26 
C: 57.39 ± 11.58
T: 22/20
C: 23
/19
CDMA + CMedicine (Chinese herbal medicine)T: once a day for 4 weeks, 30 min; drug treatment was the same as the control group
C: one dose a day for 4 weeks
HAMD, VAS, AE

Huang et al. [35]109T: 45.36 ± 2.78 
C: 45.72 ± 2.79
T: 24/31
C: 22
/32
Chinese diagnostic criteriaMA + CMedicine (Deanxit or fluoxetine + olanzapine)T: five times a week for 2 months, 30 min; drug treatment was the same as the control group
C: moderate depression: Deanxit twice a day for two months; severe depression: fluoxetine once a day for two months, olanzapine was used according to the needs of the disease
HAMD, AE

AE: adverse events; C: control group; CCMD: Chinese Classification of Mental Disorders; CD: clinical diagnosis; EA: electroacupuncture; HAMD: Hamilton Depression Scale; ICD: International Classification of Diseases; ICHD: International Classification of Headache Disorders; MA: manual acupuncture; NR: not reported; T: therapy group; VAS: Visual Analogue Scale.