Impaired Mitochondrial Bioenergetics Function in Pediatric Chronic Overlapping Pain Conditions with Functional Gastrointestinal Disorders

Table 1

Comparison in mitochondrial bioenergetic between healthy controls and youth with chronic overlapping pain conditions.

(pmol/min)	HC, median (IQR) n = 19	COPC, median (IQR) n = 31	-value
Non mitochondrial respiration	13.0 (7.9, 18.0)	9.3 (5.3, 11.7)	0.016
BR	52.3 (44.2, 69.7)	43.4 (27.1, 51.8)	0.010
SRC	117.8 (100.3, 209.7)	118.33 (69.4, 161.1)	0.281
ATP production	49.9 (43.2, 65.4)	42.7 (27.3, 50.2)	0.013
ECAR	17.1 (14.7, 24.0)	16.2 (12.1, 19.5)	0.040

ECAR = extracellular acidification rate; OCR = oxygen consumption rate; BR = basal respiratory rate; SRC = spare respiratory capacity. All mitochondrial bioenergetics measurements are in pmol/min; HC = healthy controls; COPC = chronic overlapping pain conditions; IQR = interquartile range.