Review Article
Pharmacotherapeutic Options for Managing Neuropathic Pain: A Systematic Review and Meta-Analysis
Table 2
Randomized, double-blind, controlled trials testing the effect of gabapentinoids.
| Study | Active drug | Control | Sample size | NP condition | Outcome measure | Pain outcome | Adverse events (>10%) |
| Baba et al. [11] | Mirogabalin 15/20/30 mg | Placebo | 834 | DPN | 0–10 NRS | Positive | Nasopharyngitis (16.4%), somnolence (14.5%), and dizziness (18%) | Jiang et al. [12] | Pregabalin 300–600 mg | Placebo | 128 | Radiotherapy-induced NP | 0–10 NRS | Positive | Dizziness (18.8%) and somnolence (20.3%) | Kato et al. [13] | Mirogabalin 15/20/30 mg | Placebo | 765 | PHN | 0–10 NRS | Positive | Somnolence (23.9%), nasopharyngitis (12.9), and dizziness (15.5%) | Huffman et al. [14] | Pregabalin CR 82.5–660 mg | Placebo | 413 | PHN | NPS | Positive | Dizziness (17.1%) and somnolence (11.4%) | Liu et al. [15] | Pregabalin 300 mg | Placebo | 220 | PHN | 0–10 NRS | Positive | Dizziness (24.3%) | Merante et al. [16] | Mirogabalin 15/20/30 mg | Placebo | 452 | DPN | PGIC, BPI | Positive | Dizziness (15.8%) and somnolence (12.3%) | Raskin et al. [17] | Pregabalin 150–300 mg | Placebo | 301 | DPN | 0–10 NRS | Negative | Dizziness (10.3) | Freeman et al. [18] | Gabapentin 1800 mg | Placebo | 721 | PHN | 0–100 NRS | Positive | Not reported | Holbech et al. [10] | Pregabalin 300 mg | Placebo | 69 | Painful polyneuropathy | 0–10 NRS | Positive | Dizziness (16%), oedema (16%), and weight gain (14%) |
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NP: neuropathic pain; DPN: diabetic painful neuropathy; PHN: postherpetic neuralgia; NRS: numerical rating scale; NPS: neuropathic pain scale; PGIC: patient global impression of change; BPI: brief pain inventory.
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