Pharmacotherapeutic Options for Managing Neuropathic Pain: A Systematic Review and Meta-Analysis

Table 8

Number needed to treat.

Study and drug classes	Drug	NNT	ARR
Antidepressants
Richards [9]	Venlafaxine XR 225 mg	38 (5.34; ∞; −4.15)	0.027 (−0.24; 0.19)
Holbech [10]	Imipramine 75 mg	7 (4,00; 32.51)	0.14 (0.03; 0.25)
Pooled		13 (4.07; ∞; −11.83)	0.08 (−0.09; 0.25)
Gabapentinoids
Baba [11]	Mirogabalin 30 mg	8 (4.87; 28.56)	0.12 (0.04; 0.20)
Kato [13]	Mirogabalin 30 mg	18 (32,31; ∞; −6.77)	0.06 (−0.15; 0.03)
Jiang [12]	Pregabalin 300–600	5 (2.80; 13.73)	0.22 (0.09; 0.35)
Huffman [14]	Pregabalin CR 82.5–660 mg	5 (3.69; 9.10)	0.19 (0.12; 0.27)
Liu [15]	Pregabalin 300 mg	5 (2.97; 13.54)	0.21 (0.08; 0.34)
Holbech [10]	Pregabalin 300 mg	17 (6.42; ∞; −27.42)	0.06 (−0.04; 0.16)
Pooled		9 (4.85; 31.15)	0.12 (0.03; 0.21)
Cannabinoids
Wilsey [30]	D9-THC 2.9–6.7%	2 (1.64–4.17)	0.43 (0.24; 0.61)
Wallace [32]	D9-THC 1-4-7%	5 (2.03; ∞; −8.53)	0.19 (−0.12; 0.49)
Pooled		3 (1.78; 8.77)	0.34 (0.11; 0.563)
Pickering [20]	Lidocaine patch 5%	3 (1.53; 73.83)	0.33 (0.01; 0.65)
Palladini [19]	Lidocaine patch 5%	16 (7.21; ∞; −70.24)	0.06 (−0.01; 0.14)
Demant [23]	Lidocaine patch 5%	20 (6.06; −15.41)	0.05 (−0.07; 0.17)
Pooled		13 (6.94; 76.80)	0.08 (−0.01; 0.16)
Sodium channel blockers
de Greef [33]	Lacosamide 400 mg	8 (3,40; ∞; −21,00)	0.12 (−0.05; 0.29)
Zakrzewska [35]	BIIB074 450 mg	2 (1.31; 6.72)	0.46 (0.15; 0.77)
Price [36]	TV-45070	6 (2.60; ∞; −41.3)	0.18 (−0.02; 0.38)
Pooled		5 (2.59; 22.40)	0.22 (0.05; 0.39)