Vitamin D Deficiency and Molecular Changes in Circulating MicroRNAs in Older Adults with Lower Back Pain

Figure 1

Changes in biological parameters in subjects with different LBP scores. Significant changes were reported in the expression of miRNAs; miR-146a and miR-558 were significantly downregulated and miR-155 and miR-124a were significantly upregulated in subjects with moderate to severe LBP scores compared to subjects with minimal LBP scores (a). A significant decrease in the levels of vitamin D and an increase in pain and LBP-OSW scores were reported in subjects with moderate to severe LBP, compared to those with minimal LBP scores (b). Inflammatory markers as TNF-α, IL-6, and CRP were significantly increased in subjects with moderate () and severe () LBP scores compared to normal controls (c). In addition, biosynthesis of bone metabolism markers as s-Ca, s-BAP, s-OC, and s-NTX was significantly reduced in subjects with moderate () and severe () LBP compared to subjects with minimal LBP scores (d).

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