|
| Authors | | Complementary intervention | Participants | Intervention protocol | Comparator | Sources searched | Range of included studies (years) | Overall no. of included studies | Quality and certainty assessment tools | Appraisal rating | Measurement of pain | Findings | Sig. | Heterogeneity (I2) | Publication bias |
|
| Nascimento-Júnior et al. | [11] | CT | 231 healthy patients with unilaterally or bilaterally impacted mandibular 3rd molars | CT using ice packs was applied on the surgery side of the face for 5 to 30 minutes followed by resting periods during the first 24 h to 48 h after surgery | No CT | PubMed, WoS, Scopus, CENTRAL, ClinicalTrials.gov, OpenThesis, and GL | 1985–2018 | 6 | Cochrane RoB 1 tool + GRADE evidence certainty | RoB: considerable
GRADE: low | VAS | Early: 48 h | N | 0% | NR |
| Early: 72 h | Y | 0% |
| Late: day 7 | N | 62% |
| Liu et al. | [9] | SD | 409 healthy patients with fully or partially impacted mandibular 3rd molars | SD using gauze, tube, or rubber drainage | No SD | PubMed, WoS, and CENTRAL | 1988–2016 | 10 | Cochrane RoB 1 tool | RoB: considerable | VAS | Early: 48 h–72 h | Y | 0% | Not suspected |
| Late: days 5–7 | N | 0% | Not suspected |
| Canellas et al. | [28] | PRF | 514 healthy patients with unilaterally or bilaterally impacted mandibular 3rd molars | Intrasocket application of PRF (protocol of centrifugation: 3000 rpm × 10 minutes) | No PRF application | PubMed, Embase, WoS, and CENTRAL + GL | 2010–2017 | 13 | Cochrane RoB 1 tool | RoB: moderate | VAS | Early: 72 h | Y | 79% | NR |
| Late: day 7 | Y | 0% |
| Ramos et al. | [30] | PRF/l-PRF/A-PRF | 510 healthy patients with unilaterally or bilaterally impacted mandibular 3rd molars | Intrasocket application of PRF (protocol of centrifugation: 3000 rpm × 10 minutes/2700 rpm × 12 minutes) | No PRF application | PubMed, Embase, WoS, CENTRAL, and Virtual Health Library | 2015–2021 | 17 | Cochrane RoB 1 tool | RoB: moderate | VAS | Early: 72h | Y | 68% | NR |
| Late: day 7 | N | 92% |
| Vitenson et al. | [31] | A-PRF | 132 healthy patients with unilaterally or bilaterally impacted mandibular 3rd molars | Intrasocket application of A-PRF (protocol of centrifugation: 1500 rpm × 14 minutes/1300 rpm × 13 minutes) | No PRF application/other biomaterials | MEDLINE Embase, Cochrane Library, and Scopus + GL | 2019–2021 | 4 | Cochrane RoB 2 tool + GRADE evidence certainty | RoB: low to moderate | VAS | Early: 48 h | Y | NA | NR |
| Early: 72 h | Y | 0% |
| Late: day 7 | Y | 31.04% |
| Maria de Souza et al. | [10] | HAA | 271 healthy patients with fully or partially impacted mandibular 3rd molars | 1-Hyaluronic acid gel: applied to the extraction socket (0.2 mL to 2 mL)
2-Hyaluronic acid spray: two puffs were applied to the extraction area | No HAA | CENTRAL, PubMed, Virtual Health Library, and WoS + GL | 2015–2018 | 5 | Cochrane RoB 1 tool + GRADE evidence certainty | RoB: moderate
GRADE: very low (pain)
low (trismus) | VAS | Early: 72 h | Y | 0% | NR |
| Late: day 7 | Y | 28% |
| Chaudhry et al. | [7] | OT | 173 healthy patients underwent 3rd molar surgery | OT was applied using extraoral prob, ozonated water, or topical ozone gel | No OT | MEDLINE, CENTRAL, and Google Scholar | 2013–2020 | 4 | Cochrane RoB 1 tool + GRADE evidence certainty | RoB: Considerable
GRADE: Moderate to low | VAS | Early: 72 h | Y | 82% | NR |
| Late: day 7 | Y | 79% |
| Firoozi et al. | [8] | KT | 444 healthy patients underwent 3rd molar surgery | Applying KT on lymphatic nodes and ducts nearby surgical areas on the skin | No KT | CENTRAL, PubMed, Google Scholar, and Scopus + GL | 2013–2021 | 9 | Cochrane RoB 2 tool + GRADE evidence certainty | RoB: high (pain) to moderate (swelling and trismus)
GRADE: moderate (pain) to low to very low (swelling) to moderate to high (trismus) | VAS | Early: 48 h | Y | 53% | NR |
| Early: 72 h | Y | 81% |
| Late: day 7 | N | 98% |
| Dawdy et al. | [34] | LLLT | 1060 healthy subjects underwent 3rd molar surgery | LLLT was applied intraorally, extraorally, or both | No LLLT/Sham | PubMed, Embase, CENTRAL, and ClinicalTrials.gov | 1990–2017 | 21 | Cochrane RoB 1 tool + GRADE evidence certainty | RoB: considerable
Grade: low to moderate | VAS | Early pain 48 h | Y | 95% | Not Suspected |
| Late: day 7 | Y | 87% |
| De Barros et al. | [6] | LLLT | 648 healthy subjects underwent 3rd molar surgery | LLLT was applied intraorally, extraorally, or both | No LLLT/Sham | PubMed, WoS, and CENTRAL | Up to July 2020 | 15 | Cochrane RoB 1 tool | RoB: low | VAS | Early: 48 h | Y | 21% | NR |
| Late: day 7 | Y | 78% |
|
