Decreased Gray Matter Volume in the Frontal Cortex of Migraine Patients with Associated Functional Connectivity Alterations: A VBM and rs-FC Study

Table 2

VBM results and functional connectivity results using the VBM cluster as the seed between three groups.

Method	Contrast	Brain region	Cluster size	Peak z-score	MNI coordinates (mm)
					x	y	z
VBM analysis	HC > MwoA	Left middle frontal cortex (lower)	1301	4.2	−42	57	12
		Left middle orbital frontal cortex		3.94	−48	51	−4.5
FC analysis	HC > MwoA-DI	Left middle frontal cortex (upper)	169	4.21	−27	33	45
		Left superior frontal cortex		3.29	−21	24	60
		Left posterior cingulate	192	4.11	−6	−33	36
		Right precuneus		3.44	6	−54	33
	MwoA-DA > MwoA-DI	Left superior frontal cortex	216	4.16	−30	48	42
		Left middle frontal cortex (upper)		3.86	−24	30	60
	MwoA-DA > HC	Left cerebellar lobule VI	106	4.02	−24	−60	−33