| Patient | Age-gender-type of laparoscopic surgery | Dose of ITM (mcg) | Time between ITM and symptoms (hours) | Duration of symptoms (hours) | Vital signs when symptoms were detected^ | Class of SAE | Treatment | ICU admission | Length of hospital stay (days) |
| 1 | 80-F-right hemicolectomy | 5000 | 5 | 19 | E3M6V5, 6 brpm, 7.1 kPa, 97%, 2 L min−1, 118/54, 71 bpm | S, RD | 100 mcg naloxone, at 10 and 22 hours after ITM injection | No | 8 | 2 | 73-M-rectosigmoid resection | 5000 | | | | None | | No | 8 | 3 | 72-M-rectosigmoid resection | 4000 | 4 | 24 | E4M6V5, 17 brpm, 100%, 1 L min−1, 102/31, 54 bpm | H | Norepinephrine-infusion for 24 hours | Yes | 4 | 4 | 74-F-right hemicolectomy | 5000 | 2 | 36 | E2M5V2, 8 brpm, 7.3 kPa, <70%, 0 L min−1, 100/65, 70 bpm | S, RD | Oxygen and naloxone-infusion for 36 hours | Yes | 5 | 5 | 68-F-right hemicolectomy | 3000 | | | | None | | No | 4 | 6 | 63-M-sigmoid resection | 3000 | 13 | 6 | E2M5V2, 12 brpm, 8.2 kPa, 97%, 1 L min,−1, 164/95, 94 bpm | S, RD | 100 mcg naloxone | No | 4 |
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Received benzodiazepines preoperatively. ^Displayed as Glasgow Coma Score, respiratory rate, pCO 2, SaO 2, supplemental oxygen, noninvasive blood pressure, and heart rate. Bpm: beats per minute; brpm: breaths per minute; F: female; H: hypotension, ICU: Intensive Care Unit; ITM: intrathecal morphine, M: male, RD: respiratory depression, and S: somnolence. |