Serious Adverse Events after a Single Shot of Intrathecal Morphine: A Case Series and Systematic Review
Table 2
Data from the review of literature.
Somnolence
Respiratory depression
Hypotension
N
28
54
2
Male (%)
11 (48%)
15 (38%)
1 (50%)
Age (years)
73 (63–78) [40–90]
72 (66–79) [40–90] (n = 20)
73[72–74]
Time of onset (h)
5 (2–6) [1.5–13] (n = 22)
6 (3–7) [1–24] (n = 35)
8 (4–12)
Dose (mcg)
2000 (250–5000) [60–15,000] (n = 27)
1000 (350–3000) [100–20,000] (n = 54)
2200 (400–4000)
Concomitant local anesthetics
16 (57%)
21 (40%)
2 (100%)
Systemic sedatives
7 (25%)
10 (19%)
2 (100%)
Naloxone
23 (82%)
38 (70%)
1 (50%)
Positive response to naloxone
22 (96%)
36 (95%)
1 (100%)
Dose of naloxone (mcg)
200 (100–200) [80–400] (n = 14)
300 (160–400) [80–1600] (n = 29)
400
Patients showing multiple symptoms are included in both groups. Missing data resulted in varying size of the groups and percentages are calculated over the reported data. Data is presented as N (%) or median (interquartile range) [range].
