Orofacial pain is not a disease entity, but rather a symptom of many different diseases. The underlying causes of orofacial pain, both of dental or nondental origin, can be complex, and their understanding often requires a deep knowledge. Odontogenic pain refers to pain originated from dental origin whereas non-odontogenic pain can arise from any anatomical structure (ear, nose, and throat; neuralgic pain) of the orofacial region. Sometimes, it is a symptom afferent to a disease that concerns the entire soma (for example, a body postural problem), and in these cases, the therapeutic approach must take into account pathologies in anatomical districts far from the orofacial area. For example, TMJ disorders are a musculoskeletal disorder that cause orofacial pain and disability of the cervical area and sometimes of the lower districts (trunk).

It is estimated that over 95% of cases of orofacial pain results from dental causes (i.e., toothache caused by pulpitis or a dental abscess). After dental pain, the second most common cause of orofacial pain is TMJ disorders (clicking, popping, or crepitus in the TMJs, with intra-articular inflammation, masticatory muscle pain, headache, tinnitus, impaired hearing, and earache). All other causes of orofacial pain are relatively rarer in comparison to these, although the full differential diagnosis is extensive. Clinicians must not forget that among these causes, there are some specific dental treatments, such as, for example, orthodontic treatment. In recent years, there has been a lot of research on aetiology, epidemiology, and management of orofacial pain. It is therefore clear that the diagnosis and the clinical management of orofacial pain undoubtedly requires a multidisciplinary approach (dental surgeons, ENT specialty, maxillofacial surgery, physical medicine), which is the main target of this Special Issue.

The Special Issue aims at collecting multidisciplinary approaches to the odontogenic and non-odontogenic pain of the orofacial region in basic and clinical aspects. Original research and review articles are welcome.

Potential topics include but are not limited to the following:

• Basic research on orofacial pain aetiology
• Clinical research on orofacial pain management
• Orofacial pain epidemiology with and without financial aspects
• Orofacial pain diagnostics especially with clinical assessment of diagnostic tool validity
• Current approaches to multidisciplinary management of orofacial pain
• Conservative methods for orofacial pain management
• Invasive methods for orofacial pain management
• Drug therapy in orofacial pain management
• Comorbidities in orofacial pain
• Diseases entities that can affect orofacial pain