Pain is a subjective feeling based on patients' symptoms and on the clinical evaluation of several characteristics, such as area, time trends, irradiation, possible regression after a specific therapy, and psychological effects.

Orofacial pain is one of the most common reasons for seeking medical treatment because of its influence on the quality of life. Orofacial pain is often the result of inflammatory, neoplastic, immune, infectious, or degenerative diseases, as well as temporomandibular disorders. Sometimes, orofacial pain can be difficult to differentiate from head and neck pain due to its complexity, especially when the psychosomatic state of the patient is unstable. The exploration of the characteristics and underlying mechanisms of orofacial pain will help the diagnosis and treatment of this syndrome.

This Special Issue seeks to cover the basic and clinical aspects of orofacial pain, including causes, clinical presentation, mechanistic exploration, and treatment methods. We also invite authors to submit original research and review articles about postoperative pain.

Potential topics include but are not limited to the following:

• Head and neck pathology
• Oral medicine
• Pain including headaches and muscle aches
• Pain epidemiology of temporomandibular disorders (TMDs)
• Trigeminal pains
• Current approaches to multidisciplinary management of orofacial pain
• Pharmacologic therapies for orofacial pain
• Management, such as non-steroidal anti-inflammatory drugs and antispasmodics
• Temporomandibular disorders
• Psychological aspects of pain in the orofacial area
• Treatment including non-pharmacological treatments, such as kinesitherapy, laser therapy, or manual therapy
• Prevention strategies