Development of Viral Vectors for Gene Therapy for Chronic Pain

Table 1

Analgesic effect of HSV vectors encoding therapeutic genes in pain treatment.

Pain models	Gene product	Inoculation	References
Acute pain	Preproenkephalin	To the skin of dorsal hindpaw	Wilson et al. [16]
Inflammatory pain	Preproenkephalin A	Infected on scarified hind footpads	Braz et al. [17]
Neuropathic pain	Proenkephalin A	Unilateral peripheral inoculation	Meunier et al. [21]
Cutaneous hyperalgesia	Preproenkephalin	Subcutaneous inoculation	Yeomans et al. [9]
Bladder hyperactivity and pain	Preproenkephalin	Injected into the bladder wall	Yokoyama et al. [20]
Inflammatory pain	Endomorphin-2	Subcutaneous inoculation	Hao et al. [18]
Neuropathic pain	Endomorphin-2	Subcutaneous inoculation	Wolfe et al. [19]
Neuropathic pain	IL-4	Subcutaneous inoculation	Hao et al. [23]
Neuropathic pain	sTNFRs	Subcutaneous inoculation	Peng et al. [24]
Neuropathic pain	GAD67	Subcutaneous inoculation	Hao et al. [25]
Neuropathic pain	GAD67	Subcutaneous inoculation	Liu et al. [26]
Inflammatory pain	Nav1.7 antisense	Subcutaneous inoculation	Yeomans et al. [27]
Cancer pain	Proenkephalin	Subcutaneous inoculation	Goss et al. [14]