Development of Viral Vectors for Gene Therapy for Chronic Pain

Table 2

Analgesic effect of AAV vectors encoding therapeutic genes in chronic pain treatment.

Pain models	Gene product	Inoculation	References
Neuropathic pain; Neuropathic pain; Neuropathic pain; Inflammation pain; Neuropathic pain	IL-10; shGCH1; Prepro-β-endorphin; μ-opioid receptor; BDNF	Intrathecal administration; Injected into sciatic nerve; Intrathecal administration; Injected into DRG; Injected into the dorsal horn	Milligan et al. [31]; Kim et al. [32]; Storek et al. [34]; Xu et al. [33]; Eaton et al. [35]