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Pain Research and Treatment
Volume 2012, Article ID 104782, 5 pages
http://dx.doi.org/10.1155/2012/104782
Clinical Study

Effect of Diclofenac with B Vitamins on the Treatment of Acute Pain Originated by Lower-Limb Fracture and Surgery

1Área Académica de Medicina del Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, 42090 Pachuca, HGO, Mexico
2Research and Traumatology Departments, Hospital del Niño DIF, 42090 Pachuca, HGO, Mexico
3Hospital General de los Servicios de Salud del Estado de Hidalgo, 42090 Pachuca, HGO, Mexico
4SubDirección de Investigación de los Servicio de Salud de Hidalgo, 42030 Pachuca, HGO, Mexico
5Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, IPN, 11340, DF, Mexico

Received 11 August 2011; Revised 22 September 2011; Accepted 27 September 2011

Academic Editor: María Asunción Romero Molina

Copyright © 2012 Héctor A. Ponce-Monter et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Ivani and F. Tonetti, “Postoperative analgesia in infants and children: new developments,” Minerva Anestesiologica, vol. 70, no. 5, pp. 399–403, 2004. View at Google Scholar · View at Scopus
  2. A. Beck, K. Salem, G. Krischak, L. Kinzl, M. Bischoff, and A. Schmelz, “Nonsteroidal anti-inflammatory drugs (NSAIDs) in the perioperative phase in traumatology and orthopedics. Effects on bone healing,” Operative Orthopadie und Traumatologie, vol. 17, no. 6, pp. 569–578, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. M. Curatolo and G. Sveticic, “Drug combinations in pain treatment: a review of the published evidence and a method for finding the optimal combination,” Best Practice and Research, vol. 16, no. 4, pp. 507–519, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. O. S. Levin and I. A. Moseikin, “Vitamin B complex (milgamma) in the treatment of vertebrogenic lumbosacral radiculopathy,” Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova, vol. 109, no. 10, pp. 30–35, 2009. View at Google Scholar · View at Scopus
  5. A. Kuhlwein, H. J. Meyer, and C. O. Koehler, “Reduced diclofenac administration by B vitamins: results of a randomized double-blind study with reduced daily doses of diclofenac (75 mg diclofenac versus 75 mg diclofenac plus B vitamins) in acute lumbar vertebral syndromes,” Klinische Wochenschrift, vol. 68, pp. 107–115, 1990. View at Google Scholar
  6. G. Bruggemann, C. O. Koehler, and E. M. Koch, “Results of a double-blind study of diclofenac + vitamin B1, B6, B12 versus diclofenac in patients with acute pain of the lumbar vertebrae. A multicenter study,” Klinische Wochenschrift, vol. 68, pp. 116–120, 1990. View at Google Scholar
  7. E. Pérez-Flores, R. Medina-Santillán, G. Reyes-García, and E. Mateos-García, “Combination of diclofenac plus B vitamins in acute pain after tonsillectomy: a pilot study,” Proceedings of the Western Pharmacology Society, vol. 46, pp. 88–90, 2003. View at Google Scholar · View at Scopus
  8. M. A. Mibielli, M. Geller, J. C. Cohen et al., “Diclofenac plus B vitamins versus diclofenac monotherapy in lumbago: the DOLOR study,” Current Medical Research and Opinion, vol. 25, no. 11, pp. 2589–2599, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. A. F. Garza, R. Monroy-Maya, M. Soto-Ríos et al., “A pilot study of the effect of diclofenac with B vitamins for the treatment of acute pain following lower-limb fracture and surgery,” Proceedings of the Western Pharmacology Society, vol. 51, pp. 70–72, 2008. View at Google Scholar · View at Scopus
  10. M. M. Wolfe, D. R. Lichtenstein, and G. Singh, “Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs,” New England Journal of Medicine, vol. 340, no. 24, pp. 1888–1899, 1999. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. S. Fiorucci, E. Antonelli, and A. Morelli, “Mechanism of non-steroidal anti-inflammatory drug-gastropathy,” Digestive and Liver Disease, vol. 33, no. 2, pp. S35–S43, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. D. S. Franca, A. L. S. Souza, K. R. Almeida, S. S. Dolabella, C. Martinelli, and M. M. Coelho, “B vitamins induce an antinociceptive effect in the acetic acid and formaldehyde models of nociception in mice,” European Journal of Pharmacology, vol. 421, no. 3, pp. 157–164, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. I. Jurna, K. H. Carlson, D. Bonke, Q. G. Fu, and M. Zimmermann, “Suppression of thalamic and spinal nociceptive neuronal response by pyridoxine, thiamine, and cyanocobalamin,” Annals of the New York Academy of Sciences, vol. 585, pp. 492–495, 1990. View at Publisher · View at Google Scholar · View at Scopus
  14. Z. G. Abbas and A. B. M. Swai, “Evaluation of the efficacy of thiamine and pyridoxine in the treatment of symptomatic diabetic peripheral neuropathy,” East African Medical Journal, vol. 74, no. 12, pp. 803–808, 1997. View at Google Scholar · View at Scopus
  15. H. Woelk, S. Lehrl, R. Bitsch, and W. Kopcke, “Benfotiamine in treatment of alcoholic polyneuropathy: an 8-week randomized controlled study (BAP I study),” Alcohol and Alcoholism, vol. 33, no. 6, pp. 631–638, 1998. View at Google Scholar · View at Scopus
  16. H. Okada, K. Moriwaki, Y. Kanno et al., “Vitamin B6 supplementation can improve peripheral polyneuropathy in patients with chronic renal failure on high-flux haemadialysis and human recombinant erythropoietin,” Nephrology Dialysis Transplantation, vol. 15, no. 9, pp. 1410–1413, 2000. View at Google Scholar · View at Scopus
  17. J. M. Ellis and K. Folkers, “Clinical aspects of treatment of carpal tunnel syndrome with vitamin B6,” Annals of the New York Academy of Sciences, vol. 585, pp. 302–320, 1990. View at Publisher · View at Google Scholar · View at Scopus
  18. G. L. Mauro, U. Martorana, P. Cataldo, G. Brancato, and G. Leticia, “Vitamin B12 in low back pain: a randomized, double-blind, placebo-controlled study,” European Review for Medical and Pharmacological Sciences, vol. 4, pp. 53–58, 2000. View at Google Scholar
  19. S. R. Edwards, L. E. Mather, Y. Lin, I. Power, and M. J. Cousins, “Glutamate and kynurenate in the rat central nervous system following treatments with tail ischaemia or diclofenac,” Journal of Pharmacy and Pharmacology, vol. 52, no. 1, pp. 59–66, 2000. View at Google Scholar · View at Scopus
  20. N. Voilley, J. De Weille, J. Mamet, and M. Lazdunski, “Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors,” Journal of Neuroscience, vol. 21, no. 20, pp. 8026–8033, 2001. View at Google Scholar · View at Scopus
  21. M. I. Ortiz, V. Granados-Soto, and G. Castañeda-Hernández, “The NO-cGMP-K+ channel pathway participates in the antinociceptive effect of diclofenac, but not of indomethacin,” Pharmacology Biochemistry and Behavior, vol. 76, no. 1, pp. 187–195, 2003. View at Publisher · View at Google Scholar
  22. M. R. León-Reyes, G. Castañeda-Hernández, and M. I. Ortiz, “Pharmacokinetic of diclofenac in the presence and absence of glibenclamide in the rat,” Journal of Pharmacy & Pharmaceutical Sciences, vol. 12, no. 3, pp. 280–287, 2009. View at Google Scholar · View at Scopus
  23. M. I. Ortiz, “Blockade of the antinociception induced by diclofenac, but not of indomethacin, by sulfonylureas and biguanides,” Pharmacology Biochemistry and Behavior, vol. 99, no. 1, pp. 1–6, 2011. View at Publisher · View at Google Scholar · View at PubMed
  24. G. D. Bartoszyk and A. Wild, “B-vitamins potentiate the antinociceptive effect of diclofenac in carrageenin-induced hyperalgesia in the rat tail pressure test,” Neuroscience Letters, vol. 101, no. 1, pp. 95–100, 1989. View at Google Scholar · View at Scopus
  25. G. Reyes-García, R. Medina-Santillán, F. Terán-Rosales et al., “Analgesic effect of B vitamins in formalin-induced inflammatory pain,” Proceedings of the Western Pharmacology Society, vol. 44, pp. 139–140, 2001. View at Google Scholar · View at Scopus
  26. K. Dakshinamurti, S. K. Sharma, and D. Bonke, “Influence of B vitamins on binding properties of serotonin receptors in the CNS of rats,” Klinische Wochenschrift, vol. 68, no. 2, pp. 142–145, 1990. View at Publisher · View at Google Scholar · View at Scopus
  27. P. Hartvig, K. J. Lindner, P. Bjurling, B. Langstrom, and J. Tedroff, “Pyridoxine effect on synthesis rate of serotonin in the monkey brain measured with positron emission tomography,” Journal of Neural Transmission, vol. 102, no. 2, pp. 91–97, 1995. View at Publisher · View at Google Scholar · View at Scopus
  28. Q. G. Fu, E. Carstens, B. Stelzer, and M. Zimmerman, “B vitamins suppress spinal dorsal horn nociceptive neurons in the cat,” Neuroscience Letters, vol. 95, no. 1–3, pp. 192–197, 1988. View at Google Scholar · View at Scopus
  29. S. K. Sharma, B. Bolster, and K. Dakshinamurti, “Effects of pyridoxine on nociceptive thalamic unit activity,” Annals of the New York Academy of Sciences, vol. 585, pp. 549–553, 1990. View at Publisher · View at Google Scholar · View at Scopus
  30. D. L. Vesely, “B complex vitamins activate rat guanylate cyclase and increase cyclic GMP levels,” European Journal of Clinical Investigation, vol. 15, no. 5, pp. 258–262, 1985. View at Google Scholar · View at Scopus
  31. G. Reyes-García, R. Medina-Santillan, F. Terán-Rosales et al., “B vitamins increase the anti-hyperalgesic effect of diclofenac in the rat,” Proceedings of the Western Pharmacology Society, vol. 45, pp. 147–149, 2002. View at Google Scholar · View at Scopus
  32. V. Saareks, I. Mucha, E. Sievi, and A. Riutta, “Nicotinic acid, vitamin B6 and eicosanoid production,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 358, article R726, 1998. View at Google Scholar
  33. G. Innes, M. Murphy, C. Nijssen-Jordan, J. Ducharme, and A. Drummond, “Procedural sedation and analgesia in the emergency department Canadian consensus guidelines,” Journal of Emergency Medicine, vol. 17, no. 1, pp. 145–156, 1999. View at Publisher · View at Google Scholar · View at Scopus