| Classification | No. of proteins | Genera found1 | Function characterized?2 | References |
| Ubiquitous protein families | | | | | Enzymes | | | | | Cimex apyrase | 1 | C, R(?) | Y | [26, 50] | 5′-nucleotidase | 6 | T | Y | [12, 13, 51] | Cimex NUDIX hydrolase | 3 | C | | | Secreted esterase | 5 | C, T | | | Inositol phosphate phosphatases including Cimex nitrophorins | 24 | C, T, R | Y/N | [8, 27, 28] | Serine proteases | 17 | C, T | Y/N | [30] | Chitinase | 1 | O | | | Other enzymes | 4 | T, O | | | Protease inhibitor domains | | | | | Kazal domain containing proteins | 13 | T | | | Serpin | 1 | C | | | Pacifastin-related peptide | 1 | O | | | Cystatin | 5 | O | | | Lipocalins | 331 | T, R | Y/N | [2, 4–7, 11, 14, 15, 19–21, 23, 43, 52–55] | Salivary OBP | 19 | C, T, R | | | Salivary antigen 5 family | 22 | C, T, R | | | Triatoma dimidiata lectin | 2 | T | | | Immunity related | | | | | Lysozyme | 4 | C | | | Defensin | 1 | T | | | Histidine-rich peptide | 1 | T | | | Immune-related conserved insect protein | 1 | T | | | Arthropod or insect specific families | | | | | Cuticle-like proteins and conserved mucins | 5 | T | | | Conserved insect secreted protein family | 6 | C, T, O | | | Mys2 family | 3 | R, T | | | Cimex-Triatoma family | 3 | C, T | | | Other individual proteins of conserved insect families | 4 | T | | | Hemiptera specific families | | | | | Mys3/hemolysin-like family | 16 | T, R, O | | | Triatoma-specific families | | | | | Trialysin | 8 | T | Y | [17, 18] | Short trialysin | 6 | T | | | Triatoma matogrossensis family | 2 | T | | | Triatoma matogrossensis family 2 | 2 | T | | | Orphan Triatoma proteins | 19 | T | | | Rhodnius-specific families | | | | | Orphan Rhodnius proteins, include low-complexity proteins | 3 | R | | | Cimex-specific proteins | | | | | Cimex mucin family | 2 | C | | | Orphan Cimex proteins | 1 | C | | | Oncopeltus-specific families | | | | | Oncopeltus family | 3 | O | | | Oncopeltus family 2 | 2 | O | | | Orphan Oncopeltus protein | 12 | O | | |
| Total | 559 | | | |
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