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Psyche
Volume 2018, Article ID 7814643, 7 pages
https://doi.org/10.1155/2018/7814643
Research Article

Self-Limiting OX513A Aedes aegypti Demonstrate Full Susceptibility to Currently Used Insecticidal Chemistries as Compared to Indian Wild-Type Aedes aegypti

1Gangabishan Bhikulal Investment and Trading Limited (GBIT), P.O. Box 76, Jalna-Aurangabad Road, Dawalwadi, Badnapur, Jalna, Maharashtra State 431 203, India
2Oxitec Limited, 71 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RQ, UK

Correspondence should be addressed to Prabhakargouda B. Patil; moc.aidnitibg@litap.rakahbarp

Received 17 November 2017; Accepted 22 March 2018; Published 30 April 2018

Academic Editor: David Roubik

Copyright © 2018 Prabhakargouda B. Patil et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

OX513A Aedes aegypti is a genetically engineered strain carrying a self-limiting gene. Studies in several countries have shown the effectiveness of the strain at reducing pest Aedes aegypti populations. As a component of biosafety assessments relevant to Indian environments, OX513A and two Indian wild-type Ae. aegypti strains (from Aurangabad and Delhi) were tested for susceptibility to a range of commonly used insecticides in India, such as dichlorodiphenyltrichloroethane (DDT), malathion, deltamethrin, and permethrin using World Health Organization (WHO) testing kits and following WHO standard test procedures. Knockdown times (KDT) for all compounds were determined separately for male and female adults of the three mosquito strains. Results indicated that adults of OX513A, Aurangabad, and Delhi strains were resistant to DDT, yielding mortality rates of 90.9, 87.4, and 44.4% and 70.1, 3.0, and 6.0% for male and female adults, respectively. In contrast, adults of all three strains were found to be susceptible to malathion, deltamethrin, and permethrin, exhibiting mortalities between 98 and 100%. The magnitudes of susceptibility, based on the KDT50 values, were greater in the OX513A strain, as compared to wild-type strains of Ae. aegypti for all insecticides tested. The results confirm that, aside from historical resistance to DDT, OX513A has retained full sensitivity to these commonly used compounds and exhibits responses akin to those of susceptible Indian wild-type strains.