Review Article
Epigenetic and Neural Circuitry Landscape of Psychotherapeutic Interventions
Table 3
Description of psychotherapy and neuroimaging studies: psychodynamic psychotherapy.
| | Diagnosis | Study | Number of patients (intervention group) | Design | Treatment effects of psychotherapy |
| | PD | Beutel et al. (2010) | 9 | fMRI
4 weeks (inpatient setting) | Decreased limbic and increased vPFC and OFC activity
Parameter was emotional linguistic go/no-go task |
| | MDD | Buchheim et al. (2012) | 16 (unmedicated) | fMRI
15 months | Decrease in amygdala, dmPFC, and sgACC hyperactivity | | Karlsson et al. (2010) | 8 (unmedicated) | PET
16 weeks of therapy
Comparison group received fluoxetine | Greater binding of 5-HT1A in the medial PFC and in the OFC | | Roffman et al. (2014) | 9 (treatment completers; all on antidepressants) | PET
16 weeks of dynamic therapy using the Core Conflictual Relationship Theme manual | Decrease in metabolism of right insula | | Viinamäki et al. (1998) | 1
(unmedicated)
(Likely comorbid borderline personality disorder) | SPECT
Weekly therapy for 1 year | SERT density normalization within the mPFC | | Wiswede et al. (2014) | 18
(unmedicated) | fMRI
8 months | Decrease in BG and amygdala hyperactivity to operationalized psychodynamic diagnostics (OPD) sentences |
| | BPD | Lai et al. (2007) | 5 enrolled
(2 completed)
(unmedicated) | SPECT
Weekly for 16 months | Increased perfusion in frontal cortical areas |
|
|
