Review Article
Epigenetic and Neural Circuitry Landscape of Psychotherapeutic Interventions
Table 3
Description of psychotherapy and neuroimaging studies: psychodynamic psychotherapy.
| Diagnosis | Study | Number of patients (intervention group) | Design | Treatment effects of psychotherapy |
| PD | Beutel et al. (2010) | 9 | fMRI 4 weeks (inpatient setting) | Decreased limbic and increased vPFC and OFC activity Parameter was emotional linguistic go/no-go task |
| MDD | Buchheim et al. (2012) | 16 (unmedicated) | fMRI 15 months | Decrease in amygdala, dmPFC, and sgACC hyperactivity | Karlsson et al. (2010) | 8 (unmedicated) | PET 16 weeks of therapy Comparison group received fluoxetine | Greater binding of 5-HT1A in the medial PFC and in the OFC | Roffman et al. (2014) | 9 (treatment completers; all on antidepressants) | PET 16 weeks of dynamic therapy using the Core Conflictual Relationship Theme manual | Decrease in metabolism of right insula | Viinamäki et al. (1998) | 1 (unmedicated) (Likely comorbid borderline personality disorder) | SPECT Weekly therapy for 1 year | SERT density normalization within the mPFC | Wiswede et al. (2014) | 18 (unmedicated) | fMRI 8 months | Decrease in BG and amygdala hyperactivity to operationalized psychodynamic diagnostics (OPD) sentences |
| BPD | Lai et al. (2007) | 5 enrolled (2 completed) (unmedicated) | SPECT Weekly for 16 months | Increased perfusion in frontal cortical areas |
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