Dyslipidaemia and Medical Outcome (Health Related Quality of Life) in Patients with Schizophrenia Taking Antipsychotics in Enugu, Nigeria

Table 2

Individual antipsychotics and change in lipid profile.

Variable	Mean baseline (SD)	Mean end point (SD)	Mean change	-test	df
Haloperidol
TC (mmol/L)	4.35 (.42)	4.44 (.43)	0.09	2.172	39	0.036
TG (mmol/L)	1.07 (.25)	1.25 (.30)	0.18	13.314	39	0.0001
HDL (mmol/L)	1.23 (.12)	1.15 (.12)	0.08	15.632	39	0.0001
LDL (mmol/L)	2.63 (.37)	2.72 (.39)	0.09	2.182	39	0.035
Chlorpromazine
TC (mmol/L)	4.30 (.45)	4.35 (.65)	0.05	0.405	4	0.706
TG (mmol/L)	1.11 (.26)	1.45 (.05)	0.34	4.687	4	0.009
HDL (mmol/L)	1.34 (.16)	1.04 (.00)	0.30	7.511	4	0.002
LDL (mmol/L)	2.43 (.37)	2.57 (.56)	0.14	1.057	4	0.350
Trifluoperazine
TC (mmol/L)	4.14 (.67)	4.12 (.58)	0.02	.300	2	0.792
TG (mmol/L)	1.02 (.31)	1.25 (.39)	0.23	5.111	2	0.036
HDL (mmol/L)	1.20 (.05)	1.07 (.04)	0.13	4.298	2	0.650
LDL (mmol/L)	2.46 (.49)	2.46 (.04)	0.00	0.000	2	1.000
Olanzapine
TC (mmol/L)	4.45 (.26)	5.01 (.26)	0.56	18.068	8	0.001
TG (mmol/L)	1.00 (.15)	1.40 (.19)	0.40	18.711	8	0.001
HDL (mmol/L)	1.22 (.04)	1.04 (.04)	0.18	17.097	8	0.001
LDL (mmol/L)	2.83 (.23)	3.23 (.39)	0.40	4.724	8	0.001
Risperidone
TC (mmol/L)	4.29 (.39)	4.49 (.40)	0.20	11.286	3	0.001
TG (mmol/L)	.99 (.17)	1.14 (.22)	0.15	4.469	3	0.021
HDL (mmol/L)	1.16 (.05)	1.08 (.05)	0.08	0.200	3	0.008
LDL (mmol/L)	2.74 (.39)	2.87 (.30)	0.13	2.532	2	0.085

TC = total cholesterol, TG = triglycerides, HDL = high density lipoprotein, LDL = low density lipoproteins, change = change in lipid profile (mmol/L).