Combined Parietal-Insular-Striatal Cortex Stroke with New-Onset Hallucinations: Supporting the Salience Network Model of Schizophrenia

Figure 3

The salience network. Reduced connectivity within the salience monitoring systems (ventral attention network (VAN), thalamus network (TN)) and imbalanced connectivity among the salience systems and networks involved in internal thought (default network (DN)) and external goal-direction regulation (frontoparietal network (FN)) may reflect a weakness in salience processing that contributes to the general deficits in both external goal-directed behavior and self-awareness. Meanwhile, reduced connectivity between the FN and TN, which are involved in gathering information, may underlie the loss of salient information management control. Furthermore, decreased connectivity within neural systems involved in emotion processing and hyperconnectivity between the emotion system (AN) and the salience processing system (VAN) may relate to the deficits in emotion perception and regulation. Circles refer to reduced connectivity within the corresponding networks [7].