Randomized, Placebo-Controlled, Double-Blind Pilot Study of D-Cycloserine in Chronic Stroke

Figure 1

Experimental design and time course of the study. After completing baseline testing, there were 6 visits at which medication (placebo or D-cycloserine at 100 mg dose) was dispensed. Dosing was oral and twice weekly (Monday and Wednesday) throughout the study. The study design included one session per week (Friday) in which the drug was not dispensed. Volunteers received medication immediately preceding the robotic training sessions. Final examination was administered on Day 30. + indicates medication given and − indicates no medication given. RAP: robotic-assisted physiotherapy.